Meta AnalysisID 7873
产前邻苯二甲酸酯暴露与胎儿生长的关联：一项系统评价和Meta分析
CRD42023399566
We will perform a meta-analysis to provide summarized evidence of the relationship between prenatal phthalate exposure and anthropometric measurements at birth
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7873
- Evidence Id
- 16431
- Core Evidence Id
- 16431
- Source Meta Analysis Id
- 7869
- Herb2 Meta Analysis Id
- HBMA007869
- Crd Id
- CRD42023399566
- Title
- Association of prenatal exposure to phthalates with fetal growth : A systematic review and meta-analysis
- Review Question
- We will perform a meta-analysis to provide summarized evidence of the relationship between prenatal phthalate exposure and anthropometric measurements at birth
- Study Type Included
- We will select prospective studies where the relationship between phthalate exposure during pregnancy and anthropometric measurements at birth was analyzed Exclusion criteria: Reviews, systematic reviews, meta-analyses, letters, comments, case reports, study protocols, conference papers, studies in other languages The studies inclusion strategy: Firstly, an electronic database search will be performed for the published studies. Secondly, a manual search will be done among relevant bibliography of the included papers in our systematic review.
- Condition Being Studied
- The exact mechanism of many pregnancy complications such as fetal growth restriction is still not fully understood but there is growing evidence that the environment can play an important role. The most studied environmental factors are exposure to tobacco smoke and alcohol whose negative effects on pregnancy are no longer debated. Phtalates are a group of compounds widely used in the production of industrial goods. They are commonly used as additives/stabilizing agents in cosmetics, perfumes, lotions, and pesticides. They are too used as plasticizers in the manufacture of packaging materials, polyvinylchloride (PVC), and blood transfusion devices and catheters. Pregnant women are daily exposed to these molecules whose exposure routes include inhalation, ingestion, or dermal adsorption. And data concerning the consequences on the evolution of the pregnancy of this exposure are still divergent today.
- Participant
- Pregnant women and their offspring Inclusion criteria : - Human subjects - Prenatal exposure to phthalates - Studies assess association between phthalate exposure during pregnancy, and Anthropometric measurements at birth - Exposure is measured by urine samples Exclusion criteria : - Studies not written in English or French - OR congenital anomalies - Cross-sectional studies, - Pre-conceptionnel exposition - fertility treatment - No individual analysis of exposure to phthalates
- Animal
- Human Disease Modelled
- Intervention
- The variables of interest are phthalate exposure in pregnant women with assessment in urine samples.
- Comparator Control
- Not applicable
- Main Outcome
- Relationship between phtalates exposure and anthropometric measurements at birth in regression analyses The following anthropometric measurement considered will be - Fetal growth restriction / Small for gestational age - Birth weight (g) Measures of effect Estimates from the regression analyses, OR, RR or SMDs depending on the outcome found across our research
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Female; Fetal Development; Humans; Infant, Newborn; Parturition; Phthalic Acids; Pregnancy; Prenatal Exposure Delayed Effects; phthalic acid
- Contact
- Mansoux lucile [email protected]
- Organisational Affiliation
- CHU Toulouse
- Funding Source
- Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, French
- Country
- France
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-12
- Registration Date
- 2023-03-23
- Anticipated Start Date
- 2022-10-01
- Anticipated Completion Date
- 2023-05-01
- Title Cn
- 产前邻苯二甲酸酯暴露与胎儿生长的关联：一项系统评价和Meta分析
- Title En
- Association of prenatal exposure to phthalates with fetal growth : A systematic review and meta-analysis
- Bilingual Status
- complete