Meta AnalysisID 7868
去氧肾上腺素矛盾效应的系统评价：血压升高但心输出量降低，脑血流增加但脑组织氧饱和度降低，以及再论脑血流自动调节
CRD42023432910
As one of the most commonly used drugs to treat hypotension, phenylephrine increases blood pressure but decreases cardiac output, and it increases cerebral blood flow but decreases cerebral tissue oxygen saturation. We a
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7868
- Evidence Id
- 16426
- Core Evidence Id
- 16426
- Source Meta Analysis Id
- 7865
- Herb2 Meta Analysis Id
- HBMA007865
- Crd Id
- CRD42023432910
- Title
- A systematic review of phenylephrine's paradoxical effects: increased blood pressure but decreased cardiac output, increased cerebral blood flow but decreased cerebral tissue oxygen saturation, and the revisited cerebral autoregulation
- Review Question
- As one of the most commonly used drugs to treat hypotension, phenylephrine increases blood pressure but decreases cardiac output, and it increases cerebral blood flow but decreases cerebral tissue oxygen saturation. We aim to understand and reconcile these seemingly paradoxical effects based on a systematic literature review. We also plan to revisit cerebral autoregulation based on the blood pressure and cerebral blood flow data.
- Study Type Included
- Prospective cohort or randomized studies.
- Condition Being Studied
- Patients with hypotension require phenylephrine treatment. The typical clinical settings include Operating Rooms, Intensive Care Units, and Emergency Rooms.
- Participant
- Anesthetized surgical patients, critically ill patients, or patients presented with an emergent condition complicated with hypotension.
- Animal
- Human Disease Modelled
- Intervention
- Intravenous phenylephrine treatment (bolus or infusion)
- Comparator Control
- No applicable per our review question. For this type of intervention, no treatment is the comparator.
- Main Outcome
- The main outcomes are cardiac output, cerebral blood flow, and cerebral tissue oxygen saturation. Measures of effect We will use the percentage change to quantify the changes in these variables. This percentage quantification method minimizes the difference in absolute values measured using different technologies.
- Outcome Measure
- Additional Outcome
- The additional outcomes are cerebral complications related to phenylephrine treatment. Measures of effect We use correlation analysis between changes in blood pressure and one of the interested variables (cardiac output, cerebral blood flow, and cerebral tissue oxygen saturation) to understand the effect of phenylephrine on these physiological variables.
- Study Method
- Intervention, Systematic review
- Keyword
- Cardiac Output; Cerebrovascular Circulation; Homeostasis; Humans; Hypotension; Phenylephrine
- Contact
- Lingzhong Meng [email protected]
- Organisational Affiliation
- Indiana University School of Medicine
- Funding Source
- Support was provided by institutional and/or departmental sources.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-06
- Registration Date
- 2023-06-16
- Anticipated Start Date
- 2023-06-06
- Anticipated Completion Date
- 2023-07-06
- Title Cn
- 去氧肾上腺素矛盾效应的系统评价：血压升高但心输出量降低，脑血流增加但脑组织氧饱和度降低，以及再论脑血流自动调节
- Title En
- A systematic review of phenylephrine's paradoxical effects: increased blood pressure but decreased cardiac output, increased cerebral blood flow but decreased cerebral tissue oxygen saturation, and the revisited cerebral autoregulation
- Bilingual Status
- complete