Meta AnalysisID 7867
剖宫产椎管内麻醉下去氧肾上腺素推注与输注方案对母婴结局影响的比较：一项系统评价和Meta分析
CRD42023445824
Patients - Pregnant females undergoing Cesarean Delivery under Neuraxial Anesthesia Intervention - Phenylephrine boluses to treat hypotension following neuraxial anesthesia Comparator - Prophylactic Phenylephrine infusio
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7867
- Evidence Id
- 16425
- Core Evidence Id
- 16425
- Source Meta Analysis Id
- 7864
- Herb2 Meta Analysis Id
- HBMA007864
- Crd Id
- CRD42023445824
- Title
- Comparison of Phenylephrine bolus versus infusion regimens on maternal and fetal outcomes during cesarean section under neuraxial anesthesia: A systematic review and meta-analysis
- Review Question
- Patients - Pregnant females undergoing Cesarean Delivery under Neuraxial Anesthesia Intervention - Phenylephrine boluses to treat hypotension following neuraxial anesthesia Comparator - Prophylactic Phenylephrine infusion to prevent hypotension following neuraxial anesthesia (Infusions with fixed rate, variable rate and infusion with supplementary bolus will be included) Outcomes - Primary outcome - Incidence of Maternal Hypotension Secondary outcomes Maternal outcomes - Incidence of Secondary Hypotension, Reactive Hypertension, Bradycardia, Nausea or vomiting and other adverse maternal outcomes Neonatal outcomes - Umbilical artery pH, Umbilical venous pH, Fetal acidosis, APGAR Score
- Study Type Included
- Included Studies - RCTs comparing the effect of phenylephrine bolus versus infusion regimens on maternal(Primarly blood pressure) and fetal outcomes Excluded Studies - 1.Non RCTs, Observational studies, Case reports, Letter to editor 2.Studies not providing proper description of outcomes to be assessed 3.Studies comparing Phenylephrine with other vasopressors
- Condition Being Studied
- Hypotension during cesarean section following neuraxial anesthesia
- Participant
- Inclusion criteria - Pregnant females undergoing cesarean section under neuraxial anesthesia Exclusion critera - ASA PS >3 Pre-existing cardiovascular/cerebrovascular diseases Patients with Hypertensive disorders of Pregnancy Patients with PPH Patients receiving General Anesthesia for cesarean section Patients with any contraindication to regional anesthesia such as thrombocytopenia or coagulation abnormality
- Animal
- Human Disease Modelled
- Intervention
- Phenylephrine boluses to treat hypotension following neuraxial anesthesia
- Comparator Control
- Prophylactic Phenylephrine infusion to prevent hypotension following neuraxial anesthesia (Infusions with fixed rate, variable rate and infusion with supplementary bolus will be included)
- Main Outcome
- Incidence of Maternal Hypotension Measures of effect Incidence risk ratio
- Outcome Measure
- Additional Outcome
- Maternal outcomes - Incidence of Secondary Hypotension, Reactive Hypertension, Bradycardia, Nausea or Vomiting and other adverse maternal effects Neonatal outcomes - Umbilical artery pH, Umbilical venous pH, Fetal acidosis, APGAR Score Measures of effect Incidence risk ratio - Maternal Hypotension, Hypertension, Bradycardia, Nausea or Vomiting Difference of mean - Umbilical artery and venous pH, APGAR score
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Acidosis; Apgar Score; Bradycardia; Cesarean Section; Female; Humans; Hypotension; Incidence; Infant, Newborn; Nausea; Phenylephrine; Pregnancy; Vomiting
- Contact
- Vishnu Narayanan M R [email protected]
- Organisational Affiliation
- AIIMS, New Delhi
- Funding Source
- Nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-17
- Registration Date
- 2023-07-28
- Anticipated Start Date
- 2023-07-04
- Anticipated Completion Date
- 2023-08-25
- Title Cn
- 剖宫产椎管内麻醉下去氧肾上腺素推注与输注方案对母婴结局影响的比较：一项系统评价和Meta分析
- Title En
- Comparison of Phenylephrine bolus versus infusion regimens on maternal and fetal outcomes during cesarean section under neuraxial anesthesia: A systematic review and meta-analysis
- Bilingual Status
- complete