Meta AnalysisID 7864
对羟基苯甲酸酯暴露与人体甲状腺功能的关联
CRD42023476733
Is exposure to paraben associated with increased incidence of thyroid dysfunction in humans?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7864
- Evidence Id
- 16422
- Core Evidence Id
- 16422
- Source Meta Analysis Id
- 7861
- Herb2 Meta Analysis Id
- HBMA007861
- Crd Id
- CRD42023476733
- Title
- Association between paraben exposure and thyroid function in humans
- Review Question
- Is exposure to paraben associated with increased incidence of thyroid dysfunction in humans?
- Study Type Included
- All prospective cohorts, case-control, cross-sectional, longitudinal studies in humans that investigate incidence of disturbances in thyroid function in humans after exposure to parabens will be included. Information of the exposure to parabens must be available in the articles. This means paraben or their metabolite levels has been determined in body fluid of the exposed population (e.g. saliva, urine, blood). Randomized control trials, review articles, case reports, commentaries and animal as well as in vitro studies will be excluded.
- Condition Being Studied
- Thyroid is an endocrine organ that can be adversely affected by parabens. Thyroid function can be unbalanced, and the effects are seen in the levels of thyroid hormones (T3, T4 and TSH).
- Participant
- All age groups (adults, adolescents, children, newborns) and sex (man, female) of humans that have adverse effects in thyroid function.
- Animal
- Human Disease Modelled
- Intervention
- Paraben exposure at any life stages including gestation.
- Comparator Control
- Humans with no thyroid disease/ alteration of thyroid hormone levels.
- Main Outcome
- Thyroid function, including measures of thyroid hormones levels (e.g., T3, T4), thyroid-stimulating hormone (TSH) levels or any other thyroid function tests, and related clinical phenotypes of thyroid disorders/dysfunction. Measures of effect e.g. relative risks, odds ratios
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Marjo Huovinen [email protected]
- Organisational Affiliation
- University of Eastern Finland https://www.uef.fi/en/unit/school-of-pharmacy
- Funding Source
- none Grant number(s) State the funder, grant or award number and the date of award none
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Finland
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-27
- Registration Date
- 2023-11-08
- Anticipated Start Date
- 2023-11-01
- Anticipated Completion Date
- 2024-12-31
- Title Cn
- 对羟基苯甲酸酯暴露与人体甲状腺功能的关联
- Title En
- Association between paraben exposure and thyroid function in humans
- Bilingual Status
- complete