Meta AnalysisID 7863
学龄期儿童内分泌干扰物暴露与哮喘及其加重的关联：系统评价与Meta分析
CRD42023466637
What is the relationship between the exposure to Endocrine-Disrupting Chemicals during school age and the development or exacerbation of asthma in children, and what are the main groups inducing this potential associatio
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7863
- Evidence Id
- 16421
- Core Evidence Id
- 16421
- Source Meta Analysis Id
- 7860
- Herb2 Meta Analysis Id
- HBMA007860
- Crd Id
- CRD42023466637
- Title
- Association between Endocrine Disrupting Chemical exposure in school-age children and asthma and its exacerbation: A systematic review and meta-analysis
- Review Question
- What is the relationship between the exposure to Endocrine-Disrupting Chemicals during school age and the development or exacerbation of asthma in children, and what are the main groups inducing this potential association?
- Study Type Included
- Observational studies (cross-sectional, cohorts and case controls). Abstracts with unpublished results, reviews, editorials, letters to the editor and case reports will be excluded.
- Condition Being Studied
- Exposure assessment was evaluated if cases (asthmatic children) were compared to controls (non-asthmatic children) regarding EDC exposure. They were considered cases if a doctor diagnosed them as asthmatic during the study period or if they/parents or legal guardians answered affirmatively to the following question: “Has a doctor or other health professional ever told you that you have asthma?” or had a positive bronchodilatation (at least a 12% and over 200mL increase in forced expiratory volume in 1 second (FEV1) after bronchodilation). Participants with diagnosed asthma were included in the asthma exacerbation assessment if they had two or more episodes of asthma or an asthma attack during the past 12 months, used asthma medication, reported breathing difficulties in the past three months, visited an emergency room or urgent care because of asthma, or a pediatric asthma exacerbation severity score was computed.
- Participant
- Studies were included if 1) Participants were children between 5 and 18 years (or age-adjustment was performed in the multivariate analysis); 2) At least one type of EDCs was detected during that age only; 3) Exposure was assessed in relationship with asthma prevalence or/and 4) Exposure was associated with asthma exacerbation in asthmatic children. Studies were excluded if the analyses investigated the associations between prenatal/preschool EDC exposure and asthma in neonates or children
- Animal
- Human Disease Modelled
- Intervention
- The analysis will involve 7 EDC groups: Organophosphates esters (OPE), phthalates, Polycyclic Aromatic Hydrocarbons (PAHs), particulate matter (including heavy metals), bisphenols, paraben and triclosan.
- Comparator Control
- Cases (asthmatic children) versus controls (non-asthmatic healthy children)
- Main Outcome
- Difference in the concentration of each EDC metabolite between cases and controls. Measures of effect Odds Ratios with a 95% confidence interval
- Outcome Measure
- Additional Outcome
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Georges Hatem [email protected]
- Organisational Affiliation
- Institute of Public Health of the University of Porto (ISPUP) https://ispup.up.pt/
- Funding Source
- This research was financed by the Fundação para a Ciência e a Tecnologia under a PhD student fellowship. Grant number(s) State the funder, grant or award number and the date of award Fellowship 2022.11261.BD
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Portugal
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-25
- Registration Date
- 2023-10-06
- Anticipated Start Date
- 2023-06-01
- Anticipated Completion Date
- 2024-01-01
- Title Cn
- 学龄期儿童内分泌干扰物暴露与哮喘及其加重的关联：系统评价与Meta分析
- Title En
- Association between Endocrine Disrupting Chemical exposure in school-age children and asthma and its exacerbation: A systematic review and meta-analysis
- Bilingual Status
- complete