Meta AnalysisID 7858
爱的破解：鼻内缩宫素用于伴侣治疗的临床应用的快速系统评价
CRD42023404318
Research regarding the use of the neuropeptide oxytocin via intranasal administration has demonstrated the intervention's ability to influence pro-social behavior in humans. Literature on the varying behavioral effects o
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7858
- Evidence Id
- 16416
- Core Evidence Id
- 16416
- Source Meta Analysis Id
- 7856
- Herb2 Meta Analysis Id
- HBMA007856
- Crd Id
- CRD42023404318
- Title
- Love-Hacking: Rapid Systematic Review of the Clinical Application of Intranasal Oxytocin for Couples Therapy
- Review Question
- Research regarding the use of the neuropeptide oxytocin via intranasal administration has demonstrated the intervention's ability to influence pro-social behavior in humans. Literature on the varying behavioral effects of administering intranasal oxytocin to heterosexual couples is an emerging topic. This rapid systematic review aims to appraise the current findings on administering intranasal oxytocin in heterosexual couples to identify the reported positive and negative effects on pro-social behaviors integral to modulating a healthy relationship, and reveal any possible clinical applications for the use of oxytocin as a therapy intervention. As a secondary review question, sex differences in the findings will be identified and appraised.
- Study Type Included
- RCT study designs are preferred, but all types are eligible for inclusion if they meet the above criteria. Meta-analysis and systematic reviews will be excluded, but references will be screened for studies meeting inclusion criteria.
- Condition Being Studied
- The administration of intranasal oxytocin has the potential to be a therapy intervention for couples counseling. Couples with one or both individuals suffering from substance abuse issues have been identified as targeted audiences for the intervention, but the aim of the current rapid review is to identify and assess what couples should be considered for future treatment. Studies that measure and compare oxytocin levels, but do not administer any supplemental oxytocin will not be considered eligible for review.
- Participant
- Inclusion: Adult participants in heterosexual relationships Exclusion: Homosexual relationships; Adolescents
- Animal
- Human Disease Modelled
- Intervention
- Interventions of intranasal oxytocin of any dose (IU) to either one or both individuals of a romantic dyadic relationship will be included. Alternative administering of oxytocin will be excluded.
- Comparator Control
- The behavioral effects on relationship dynamics from administered intranasal oxytocin will be compared to the respective placebo/control condition. For studies without control groups, this will be clearly identified. Couples should be assessed as one unit, but studies that compare individual response differences will be included. Studies where only one sex is examined and reported will be excluded unless partner is involved in study.
- Main Outcome
- The main outcomes of the review will be the positive or negative effects of oxytocin on relationship regulating behaviors and their measures (i.e. conflict resolution; eye-contact, aggression, etc.). Positive alterations to behavior measures that benefit the relationship will be identified and compiled (i.e. increased eye contact, decrease in aggression, etc.). Negative or nonsignificant alterations that do not benefit or decrease the quality of the relationship will be identified and compiled (i.e. decreased eye contact, increased aggression, etc.). Positive or negative impact outcome will be evaluated based on the behaviors contribution to overall relationship quality (high-impact, moderate-impact, low-impact). Outcomes will be categorized by emotional, behavioral, or physiological impact on relationship. Measures of effect Relationship measures indicated in the original manuscript will be measured by their respective odd ratio. All outcome measures including proportions, standard deviations, standard errors, confidence intervals, and confounding adjustments will be recorded.
- Outcome Measure
- Additional Outcome
- Sex dependent behaviors will be explicitly stated. Sex differences are expected and will be reported in consideration to overall improvement of relationship (i.e. If female was positively affected while male was negatively affected, but overall relationship quality was improved). Measures of effect
- Study Method
- Meta-analysis, Narrative synthesis, Systematic review, Other
- Keyword
- Administration, Intranasal; Female; Heterosexuality; Humans; Love; Male; Neuropeptides; Oxytocin
- Contact
- Nicole Jennings [email protected]
- Organisational Affiliation
- University of Hawaii at Manoa
- Funding Source
- Not applicable Grant number(s) State the funder, grant or award number and the date of award Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-21
- Registration Date
- 2023-04-01
- Anticipated Start Date
- 2023-01-09
- Anticipated Completion Date
- 2023-04-15
- Title Cn
- 爱的破解：鼻内缩宫素用于伴侣治疗的临床应用的快速系统评价
- Title En
- Love-Hacking: Rapid Systematic Review of the Clinical Application of Intranasal Oxytocin for Couples Therapy
- Bilingual Status
- complete