Meta AnalysisID 7855
硝苯地平、拉贝洛尔和甲基多巴不同剂量方案治疗妊娠期轻中度高血压的结局比较：系统评价和网状Meta分析
CRD42023447162
Comparison of outcomes of different dose regimens of of nifedipine, labetalol, and methyldopa in mild to moderate hypertension during pregnancy: a systematic review and network meta-analysis
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7855
- Evidence Id
- 16413
- Core Evidence Id
- 16413
- Source Meta Analysis Id
- 7852
- Herb2 Meta Analysis Id
- HBMA007852
- Crd Id
- CRD42023447162
- Title
- Comparison of outcomes of different dose regimens of of nifedipine, labetalol, and methyldopa in mild to moderate hypertension during pregnancy: a systematic review and network meta-analysis
- Review Question
- Comparison of outcomes of different dose regimens of of nifedipine, labetalol, and methyldopa in mild to moderate hypertension during pregnancy: a systematic review and network meta-analysis
- Study Type Included
- All studies that met the following criteria were included :1) Randomized controlled trials; 2) The subjects were women who had mild to moderate gestational hypertension during pregnancy and required immediate treatment; 3) ①Oral labetalol versus nifedipine ② oral labetalol versus methyldopa ③ oral labetalol versus placebo ④Oral nifedipine versus methyldopa ⑤ oral nifedipine versus placebo/no meditation ⑥ oral methyldopa versus placebo; 4) Provide a clear dosage plan; 5) Outcome measures included information on maternal-fetal safety assessment.
- Condition Being Studied
- we conducted a systematic review and network meta-analysis to compare maternal-fetal outcomes of different dosing regimens of nifedipine, labetalol, and methyldopa to determine the optimal treatment regimen for mild to moderate gestational hypertension. Mild to moderate gestational hypertension is defined as SBP 140-159mmHg and/or DBP 90-109mmHg during pregnancy.
- Participant
- All studies that met the following criteria were included :1) Randomized controlled trials; 2) The subjects were women who had mild to moderate gestational hypertension during pregnancy and required immediate treatment; 3) ①Oral labetalol versus nifedipine ② oral labetalol versus methyldopa ③ oral labetalol versus placebo ④Oral nifedipine versus methyldopa ⑤ oral nifedipine versus placebo/no meditation ⑥ oral methyldopa versus placebo; 4) Provide a clear dosage plan; 5) Outcome measures included information on maternal-fetal safety assessment.
- Animal
- Human Disease Modelled
- Intervention
- Oral labetalol
- Comparator Control
- oral methyldopa，oral placebo，Oral nifedipine，no meditation
- Main Outcome
- The outcome indicators were mainly safety indicators of pregnant women: hospital admissions, cesarean section, maternal death.
- Outcome Measure
- Additional Outcome
- Neonatal safety indexes: perinatal death, Apgar Score <7 at 5 min, Small for gestational age, NICU Admissions, Perinatal mortality.
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Antihypertensive Agents; Female; Humans; Hypertension; Labetalol; Methyldopa; Nifedipine; Pregnancy
- Contact
- Gideon Chan [email protected]
- Organisational Affiliation
- Guangzhou Medical University
- Funding Source
- Guangzhou Medical University
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-20
- Registration Date
- 2023-07-31
- Anticipated Start Date
- 2023-07-20
- Anticipated Completion Date
- 2023-08-25
- Title Cn
- 硝苯地平、拉贝洛尔和甲基多巴不同剂量方案治疗妊娠期轻中度高血压的结局比较：系统评价和网状Meta分析
- Title En
- Comparison of outcomes of different dose regimens of of nifedipine, labetalol, and methyldopa in mild to moderate hypertension during pregnancy: a systematic review and network meta-analysis
- Bilingual Status
- complete