Meta AnalysisID 7851
四种常用口服营养补充剂改善男性不育症精子质量的有效性：随机对照试验的网状Meta分析
CRD42023437596
This study aimed to compare the effects of four nutritional supplements (inositol, coenzyme, vitamin D, vitamin E) on male semenThis study aimed to compare the effects of four nutritional supplements (inositol, coenzyme,
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7851
- Evidence Id
- 16409
- Core Evidence Id
- 16409
- Source Meta Analysis Id
- 7848
- Herb2 Meta Analysis Id
- HBMA007848
- Crd Id
- CRD42023437596
- Title
- The effectiveness of four commonly used oral nutraceuticals in improving the Sperm quality in male infertility: a network Meta-analysis of Randomized Controlled Trials
- Review Question
- This study aimed to compare the effects of four nutritional supplements (inositol, coenzyme, vitamin D, vitamin E) on male semenThis study aimed to compare the effects of four nutritional supplements (inositol, coenzyme, vitamin D, vitamin E) on semen in male infertility patients
- Study Type Included
- RCT
- Condition Being Studied
- Infertility is defined as being unable to conceive after 12 months of regular (at least twice weekly) unprotected intercourse . Male infertility is due to abnormal sperm parameters in the male partner and are estimated to be present in about 50% of cases . Insulin resistance has been recognized as a key contributor to the disease since infertile men are closely related to the occurrence of metabolic syndrome and diabetes . Currently, certain nutraceuticals such as coenzyme Q10 (CoQ10), vitamin E(VE), vitamin D(VD), inositols, in particular myo-inositol (MI), have received widespread attention owing to their potential benefits in improving insulin resistance and ameliorating the sperm quality and metabolic disorders for male infertility
- Participant
- The inclusion criteria for this study were as follows: (i) type of studies, randomized clinical trials (RCTs) only, without limitations regarding the race or area constraints, but the language must be English; (ii) Infertile males with abnormal semen parameters; (iii) intervention:CoQ10, vitamin E, vitamin D, or inositols (MI or DCI) for the experimental group and placebo for the control group; (iv) target parameter, at least one parameter including sperm concentration, sperm motility, Sperm count, Semen volume and sperm morphology; Furthermore, the exclusion criterion was: (i)cointervention with other fertility-enhancing drugs being inapplicable to all intervention arms; (ii)studies with partially missing relevant data.
- Animal
- Human Disease Modelled
- Intervention
- intervention:CoQ10, vitamin E, vitamin D, or inositols (MI or DCI) for the experimental group
- Comparator Control
- placebo for the control group
- Main Outcome
- sperm concentration, sperm motility, Sperm count, Semen volume and sperm morphology
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Coenzymes; Dietary Supplements; Humans; Infertility, Male; Inositol; Male; Randomized Controlled Trials as Topic; Semen; Tocopherols; Vitamins
- Contact
- Hu Junping [email protected]
- Organisational Affiliation
- School of Nursing, Lanzhou University
- Funding Source
- no
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-18
- Registration Date
- 2023-06-29
- Anticipated Start Date
- 2023-06-01
- Anticipated Completion Date
- 2023-11-01
- Title Cn
- 四种常用口服营养补充剂改善男性不育症精子质量的有效性：随机对照试验的网状Meta分析
- Title En
- The effectiveness of four commonly used oral nutraceuticals in improving the Sperm quality in male infertility: a network Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete