Meta AnalysisID 7847
黏多糖贮积症患者不同治疗策略的安全性、疗效和有效性结局：随机对照试验的系统评价和网状Meta分析
CRD42023470374
Safety, efficacy, and effectiveness outcomes of different treatment strategies in patients with mucopolysaccharidosis:a systematic review and network meta-analysis of randomized controlled trials
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7847
- Evidence Id
- 16405
- Core Evidence Id
- 16405
- Source Meta Analysis Id
- 7845
- Herb2 Meta Analysis Id
- HBMA007845
- Crd Id
- CRD42023470374
- Title
- Safety, efficacy and effectiveness outcomes of different treatment strategies in mucopolysaccharidosis patients: a systematic review and network meta-analysis of randomized control trials.
- Review Question
- Safety, efficacy, and effectiveness outcomes of different treatment strategies in patients with mucopolysaccharidosis:a systematic review and network meta-analysis of randomized controlled trials
- Study Type Included
- randomized controlled trials
- Condition Being Studied
- Mucopolysaccharidosis(MPS) is a lysosomal accumulation disease caused by defects in lysosomal hydrolases and inhibiting the degradation of acidic mucopolysaccharides (glucosaminoglycans), which leads to the accumulation of mucopolysaccharides in the body and results in a series of clinical symptoms. Patients with mucopolysaccharide storage syndrome have some clinical symptoms and imaging features due to excessive accumulation of mucopolysaccharides in tissues or organs such as bone and cartilage, which affects the normal development of these tissues or organs. Mucopolysaccharide storage syndrome is a congenital or primary metabolic disorder syndrome.
- Participant
- Patients with mucopolysaccharidosis that included in randomized studies.
- Animal
- Human Disease Modelled
- Intervention
- Enzyme replacement therapies or other disease treatment therapies.
- Comparator Control
- Placebo or no treatment.
- Main Outcome
- The primary efficacy endpoint variable were the 3MSC, urine GAG and 12MWT. Measures of effect Continuous variable and incidence rate.
- Outcome Measure
- Additional Outcome
- Secondary efficacy endpoints included cognitive function and respiratory function. Measures of effect Continuous variable and incidence rate.
- Study Method
- Meta-analysis荟萃分析, Systematic review系统评价
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Lingling Huang [email protected]
- Organisational Affiliation
- Southeast University
- Funding Source
- Research on Data Mining and Risk Prediction of Pharmacovigilance (Project ref 22/05/7).Funding provided by Shenzhen Institute of Pharmacovigilance and Risk Management Institute. Grant number(s) State the funder, grant or award number and the date of award
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-21
- Registration Date
- 2023-11-01
- Anticipated Start Date
- 2023-10-21
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 黏多糖贮积症患者不同治疗策略的安全性、疗效和有效性结局：随机对照试验的系统评价和网状Meta分析
- Title En
- Safety, efficacy and effectiveness outcomes of different treatment strategies in mucopolysaccharidosis patients: a systematic review and network meta-analysis of randomized control trials.
- Bilingual Status
- complete