Meta AnalysisID 7845
高渗盐水或甘露醇治疗儿童创伤性脑损伤
CRD42023471457
Which hypertonic saline or mannitol is better to reduce intracranial pressure, increase cerebral perfusion and determine a good grade on Glasgow Coma Scale in children with traumatic brain injury?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7845
- Evidence Id
- 16403
- Core Evidence Id
- 16403
- Source Meta Analysis Id
- 7843
- Herb2 Meta Analysis Id
- HBMA007843
- Crd Id
- CRD42023471457
- Title
- Hypertonic saline or mannitol for traumatic brain injury in children
- Review Question
- Which hypertonic saline or mannitol is better to reduce intracranial pressure, increase cerebral perfusion and determine a good grade on Glasgow Coma Scale in children with traumatic brain injury?
- Study Type Included
- Randomized controlled trials and cohort studies.
- Condition Being Studied
- Despite multiple studies about the efficacy of hyperosmolar therapy in adults with traumatic brain injury, this treatment in children is not clear. These population , children with traumatic brain injury, is not so studied as adult population. Therefore, trials typically lack enough power for a definitive treatment of children in this situation, especially in analysis of outcomes as difference in Glasgow Coma Scale and the follow-up of neurological function of this patients . Due to this, we aim to perform a systematic review and meta-analysis examining the efficacy of hypertonic saline versus mannitol in children with traumatic brain injury, specifically interested in differences in Glasgow Coma Scale before and afterthe treatmente, the follow-up of neurological function, as well as the outcomes of reduce in intracranial pressure and increase in cerebral perfusion pressure.
- Participant
- We will include randomized controlled trials (RCTs) and cohort studies comparing hypertonic saline with mannitol in pediatric patients with traumatic brain injury, reporting the clinical outcomes of interest. We will exclude studies with overlapping patient populations, without pediatric population, as well as studies comparing different doses of same hyperosmolar solution and results from studies that combine hypertonic saline with mannitol.
- Animal
- Human Disease Modelled
- Intervention
- Hypertonic saline, HTS, NaCl or sodium chloride.
- Comparator Control
- Mannitol, D-mannitol, mannite, osmitrol, manna sugar, cordycepic acid or osmofundin.
- Main Outcome
- We will extract data for a pooled analysis on the following outcomes: (1) reduction in intracranial pressure ; (2) increase in cerebral perfusion pressure; (3) number of doses per day and (4) glasgow coma scale (survival with ou without disability). Measures of effect Odds ratio.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Adriele Ribeiro [email protected]
- Organisational Affiliation
- Universidade do Grande Rio Professor José de Souza Herdy - UNIGRANRIO
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-24
- Registration Date
- 2023-11-08
- Anticipated Start Date
- 2023-09-15
- Anticipated Completion Date
- 2023-12-24
- Title Cn
- 高渗盐水或甘露醇治疗儿童创伤性脑损伤
- Title En
- Hypertonic saline or mannitol for traumatic brain injury in children
- Bilingual Status
- complete