Meta AnalysisID 7792
黑棘皮病不同治疗方式有效性的比较：系统评价与Meta分析
CRD42023444441
Among patients diagnosed with Acanthosis Nigricans , What is the most effective treatment for Acanthosis Nigricans compared to tretinoin ?
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Record Fields
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- Meta Analysis Id
- 7792
- Evidence Id
- 16350
- Core Evidence Id
- 16350
- Source Meta Analysis Id
- 7790
- Herb2 Meta Analysis Id
- HBMA007790
- Crd Id
- CRD42023444441
- Title
- Comparison on the Effectiveness of different Treatment modalities for Acanthosis Nigricans: A Systematic Review and Meta-analysis
- Review Question
- Among patients diagnosed with Acanthosis Nigricans , What is the most effective treatment for Acanthosis Nigricans compared to tretinoin ?
- Study Type Included
- Randomized controlled trials (RCTs).
- Condition Being Studied
- Acanthosis Nigricans(AN) is a skin condition that manifests as thickened hyperpigmented plaques with irregular borders. It commonly affects intertriginous areas of the body, such as the neck and axillae[1].It is associated with insulin resistance, diabetes mellitus, or the use of certain medications such as glucocorticoids and oral contraceptives.Different autoimmune disorders like SLE, Sjogren's syndrome, scleroderma or Hashimoto's thyroiditis have been also linked to acanthosis nigricans[2]. While therapy focuses on treating the underlying cause, cosmetic treatment of acanthosis nigricans lesions is usually patients’ primary concern[3]. Various therapies have been introduced for the treatment of AN. Local options include topical retinoids, topical vitamin D analogs, urea, chemical peels, and different types of laser. Systemic agents such as oral retinoids, metformin, and rosiglitazone can also be used for AN plaques. Although different therapeutic modalities have shown improvement, an optimal approach to treatment remains unclear[4]. The aim of our study is to compare the effectiveness of different treatment modalities for Acanthosis Nigricans.
- Participant
- All age groups diagnosed with Acanthosis Nigricans (AN) of the neck, mild to moderate severity were included.
- Animal
- Human Disease Modelled
- Intervention
- Urea , Fractional 1550-nm erbium fiber laser , fractional carbon dioxide laser , glycolic acid , chemical peeling , Trichloroacetic acid , salicylic acid, and fractional CO2 laser.
- Comparator Control
- Tretinoin
- Main Outcome
- -To evaluate severity Acanthosis Nigricans Area and Severity Index (ANASI) score were used. -To express treatment efficacy using Melanin (M) indices and erythema (E) indices , and The narrowband reflectance spectrophotometer (Mexameter MX18) -To evaluate overall success rate The investigator's global evaluation (IGE) and participant's global evaluation (PGE) scale were used.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Acanthosis Nigricans; Humans; Insulin Resistance; Treatment Outcome; Tretinoin
- Contact
- Rose Alraddadi [email protected]
- Organisational Affiliation
- College of medicine, King Saud University for Health Science, Jeddah, Saudi Arabia
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Saudi Arabia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-13
- Registration Date
- 2023-07-23
- Anticipated Start Date
- 2023-07-02
- Anticipated Completion Date
- 2024-07-31
- Title Cn
- 黑棘皮病不同治疗方式有效性的比较：系统评价与Meta分析
- Title En
- Comparison on the Effectiveness of different Treatment modalities for Acanthosis Nigricans: A Systematic Review and Meta-analysis
- Bilingual Status
- complete