Meta AnalysisID 7790
抗氧化剂治疗特应性皮炎的疗效和安全性：随机对照试验的系统评价与网状Meta分析
CRD42023424306
This meta-analysis aimed to assess the efficacy and safety profile of antioxidants in the treatment of atopic dermatitis through a network meta-analysis
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7790
- Evidence Id
- 16348
- Core Evidence Id
- 16348
- Source Meta Analysis Id
- 7788
- Herb2 Meta Analysis Id
- HBMA007788
- Crd Id
- CRD42023424306
- Title
- Efficacy and safety profile of antioxidants in the treatment of atopic dermatitis: A systematic review and network meta-analysis of randomized controlled trials
- Review Question
- This meta-analysis aimed to assess the efficacy and safety profile of antioxidants in the treatment of atopic dermatitis through a network meta-analysis
- Study Type Included
- RCTs or cohort studies
- Condition Being Studied
- Atopic dermatitis (AD) a chronic inflammatory skin condition characterized by pruritus, eczema, and dry skin，involving complex interactions between immunologic, hereditary, and environmental influences. With an increasing prevalence during the past decades, atopic dermatitis has become a global health issue.Traditional drugs for AD treatment are antihistamines and immunomodulators that reduce skin inflammation, such as local or oral corticosteroids or calcineurin inhibitors . However, these medications are limited by considerable side effects and poor patient compliance. And it's been shown in some studies that higher antioxidant nutritional status reduces the risk of AD .Nonetheless, the results of intervention studies using antioxidants in AD are controversial.
- Participant
- Inclusion criteria were as follows: (1) Patients diagnosed with AD of any age; (2) Patients in the intervention group received at least one of the antioxidants (in any form, dose, or duration): probiotics, vitamin, melanin, or a combination of these supplements; (3) Patients in the control group received either placebo or standard treatment. If patients in both intervention groups and control groups received general adjuvant therapy at the same time, the adjuvant therapy should be the same; (4) Studies reported at least one of the following outcomes:SCORAD index, total IgE, EASI score, or Investigator’s Global Assessment. (5)From observational studies, serum 25(OH)D levels in AD patients versus HC. (6)Thelanguage of the studies was limited to English. Exclusion criteria were as follows: (1) Studies with unclear diagnostic and efficacy criteria； (2) Studies that were review articles, case reports, descriptive studies, opinion articles, or abstracts； (3) Studieswith incomplete or erroneous data that could not be merged.
- Animal
- Human Disease Modelled
- Intervention
- Patients in the intervention group received at least one of the antioxidants (in any form, dose, or duration): probiotics, vitamin, melanin, or a combination of these supplements;
- Comparator Control
- Patients in the control group received either placebo or standard treatment. If patients in both intervention groups and control groups received general adjuvant therapy at the same time, the adjuvant therapy should be the same.
- Main Outcome
- such as SCORAD index, total IgE, EASI score, or Investigator's Global Assessment.
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Shuang DU [email protected]
- Organisational Affiliation
- Affiliated Hospital of North Sichuan Medical College
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-01
- Registration Date
- 2023-12-12
- Anticipated Start Date
- 2023-05-04
- Anticipated Completion Date
- 2024-01-01
- Title Cn
- 抗氧化剂治疗特应性皮炎的疗效和安全性：随机对照试验的系统评价与网状Meta分析
- Title En
- Efficacy and safety profile of antioxidants in the treatment of atopic dermatitis: A systematic review and network meta-analysis of randomized controlled trials
- Bilingual Status
- complete