Meta AnalysisID 7779
硫酸镁与右美托咪定作为局部麻醉药佐剂在外周神经阻滞中的术后镇痛效能与安全性比较：随机对照试验的Meta分析
CRD42023449108
What is the comparative efficacy and safety of Magnesium Sulfate and dexmedetomidine as an adjuvant to local anaesthetic in peripheral nerve blocks?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7779
- Evidence Id
- 16337
- Core Evidence Id
- 16337
- Source Meta Analysis Id
- 7775
- Herb2 Meta Analysis Id
- HBMA007775
- Crd Id
- CRD42023449108
- Title
- Postoperative analgesic efficacy and safety of Magnesium Sulfate versus Dexmedetomidine as an additive to Local Anaesthetic in Peripheral Nerve Blocks: A Meta-Analysis of Randomised Controlled Trial
- Review Question
- What is the comparative efficacy and safety of Magnesium Sulfate and dexmedetomidine as an adjuvant to local anaesthetic in peripheral nerve blocks?
- Study Type Included
- Inclusion criteria: • All randomised control trials comparing efficacy and/or safety of Magnesium Sulfate and dexmedetomidine as an adjuvant to local anaesthetic in any kind of peripheral nerve blocks. Exclusion criteria: • Studies administering magnesium Sulfate and dexmedetomidine through neuraxial and other routes (e.g, intravenous administration) • Studies using autonomic nerve blocks • Observational and non-interventional studies, case series, case reports, review articles • Single-arm studies • Duplicate studies (in such cases, studies with the most up-to-date and largest data will be included)
- Condition Being Studied
- Peripheral nerve blocks (PNB) are used for providing anaesthesia in specific body area for conducting surgery, performed either by landmark or ultrasound guided technique.Local anaesthetic blocks transmission in nerve pathways. Adjuvants are the agents which are used to enhance the quality and efficacy of regional techniques.These work synergistically to quicken the onset, increase duration of analgesia, improve quality of analgesia, and limit potential medication related adverse effects. Dexmedetomidine and magnesium sulfate has also shown to prolong the duration of block and post-operative analgesia when added to local anaesthetic in various upper (interscalene, suprascapular, infraclavicular, axillary nerve block) and lower extremity (lumbar plexus block, femoral nerve block, fascia iliaca, obturator nerve, popliteal, saphenous) regional blocks. Adjuvants like dexmedetomidine, dexamethasone , fentanyl, magnesium sulfate has also shown to enhance the efficacy of local anaesthetic in abdominal nerve blocks (transversus abdominis plane, subcostal, rectus, ilioinguinal and iliohypogastric, transversalis fascia plane, and quadratus lumborum block). Studies are available that have compared the magnesium sulfate and dexmedetomidine as an adjuvants in Peripheral nerve blocks for postoperative analgesia. So, we planned a meta-analysis to Compare magnesium sulfate and dexmedetomidine as an adjuvants in in peripheral nerve block for postoperative analgesia .
- Participant
- Inclusion criteria: • The adult population of more than 18 years undergoing surgery of upper limb, lower limb, abdominal, gynaecological or thoracic surgery under regional anaesthesia or general anaesthesia. • Patients undergoing any nerve block (nerve plexus block of either brachial, lumbar or cervical, myofascial plane block, thoracic nerve blocks etc ) and any administration techniques (blinded or USG guided approach) Exclusion criteria: • Patients undergoing emergency Surgery • Patients on either chronic or acute magnesium sulfate medication or dexmedetomidine medication • Paediatric population
- Animal
- Human Disease Modelled
- Intervention
- • Magnesium sulfate as an adjuvant to local anaesthetic in peripheral nerve block regardless of dosage, volume or type of local anaesthetic.
- Comparator Control
- • Dexmedetomidine as an adjuvant to local anaesthetic in nerve block regardless of dosage, volume or type of local anaesthetic
- Main Outcome
- • Duration of analgesia: Meta-analytic summary of mean difference (95% CI) in the duration of analgesia between dexmedetomidine and Magnesium sulfate as an adjuvant to local anaesthetic in peripheral nerve block. • Onset of sensory and motor block: Meta-analytic summary of mean difference (95% CI) in the onset of sensory and motor block between dexmedetomidine and Magnesium sulfate as an adjuvant to local anaesthetic in peripheral nerve block. • Duration of sensory and motor block: Meta-analytic summary of mean or standardized mean difference (95% CI) in the duration of sensory and motor block between dexmedetomidine and Magnesium sulfate as an adjuvant to local anaesthetic in peripheral nerve block.
- Outcome Measure
- Additional Outcome
- • Adverse events: Total number of adverse events(Sedation, Intraoperative or postoperative complications, Pneumothorax, Vascular puncture, Horner syndrome, Somnolence, Bradycardia , Hypotension, Post operative nausea vomitiong) in each study arm will be considered as a numerator and the total number of patients in each study arm will be considered as a denominator. The meta-analytic summary will be presented as a risk ratio (95% CI). • 24 hr Post operative analgesic consumption • Quality of Anaesthesia :It will be presented as a risk ratio (95% CI).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- Vijeta Bajpai [email protected]
- Organisational Affiliation
- All India Institute of Medical Sciences ,Gorakhpur
- Funding Source
- nil Grant number(s) State the funder, grant or award number and the date of award What is the comparative efficacy and safety of Magnesium Sulfate and dexmedetomidine as an adjuvant to local anaesthetic in peripheral nerve blocks?nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-27
- Registration Date
- 2023-08-06
- Anticipated Start Date
- 2023-08-31
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 硫酸镁与右美托咪定作为局部麻醉药佐剂在外周神经阻滞中的术后镇痛效能与安全性比较：随机对照试验的Meta分析
- Title En
- Postoperative analgesic efficacy and safety of Magnesium Sulfate versus Dexmedetomidine as an additive to Local Anaesthetic in Peripheral Nerve Blocks: A Meta-Analysis of Randomised Controlled Trial
- Bilingual Status
- complete