Meta AnalysisID 7778
硫酸镁对脊柱手术后疼痛的影响
CRD42023462159
The PICO question that will guide the search of evidence is: For patients undergoing spine surgery, what effect does intravenous (IV) magnesium sulfate have on pain scores compared to patients that did not receive IV mag
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Record Fields
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- Meta Analysis Id
- 7778
- Evidence Id
- 16336
- Core Evidence Id
- 16336
- Source Meta Analysis Id
- 7780
- Herb2 Meta Analysis Id
- HBMA007780
- Crd Id
- CRD42023462159
- Title
- The Effect of Magnesium Sulfate on Postoperative Pain in Spine Surgery
- Review Question
- The PICO question that will guide the search of evidence is: For patients undergoing spine surgery, what effect does intravenous (IV) magnesium sulfate have on pain scores compared to patients that did not receive IV magnesium sulfate intraoperatively?
- Study Type Included
- These are the inclusion and exclusion criteria of the review. Clinical trials will be included in the review and meta-analysis if the following criteria are met: 1. Randomized controlled trials (RCT) and pre-appraised systematic review with meta-analysis. 2. Studies with patients undergoing spine surgery 3. The use of intravenous magnesium sulfate. 4. A comparison of either a placebo or no intravenous magnesium sulfate. Studies will not be included in the review and meta-analysis if the following criteria are met: 1. Case studies, case reports, or case series. 2. Narrative reviews. 3. Observational and retrospective studies. 4. Editorial, expert opinions, and commentaries.
- Condition Being Studied
- Surgical pain is an inevitable outcome of spine surgery, despite continuous efforts to incorporate multimodal analgesia with intraoperative and postoperative opioid administration. Spine surgeries are commonly performed procedures, so managing the postoperative pain that is accompanied is important for enhancing the overall quality of the surgical experience. Though opioids have been a mainstay of postoperative pain management, the association with adverse effects, including but not limited to respiratory depression, constipation, and dizziness, are key factors for why a review of other pain management strategies is paramount. It is crucial for anesthesia providers to constantly evolve with the best pain management practices to provide the safest, most effective, patient-specific plan to minimize pain. Studies have shown that 20% of spine surgery patients have reported only slightly improved preoperative pain, and many go on to develop chronic pain. With adequate postoperative pain management, these patients are more satisfied with their care, are able to recover faster and avoid serious complications. Postoperative pain control is imperative in optimizing spine surgery patient outcomes, and all avenues of adequate pain management should be utilized.
- Participant
- The population of the study is limited to spine surgery patients.
- Animal
- Human Disease Modelled
- Intervention
- Administration of intravenous magnesium sulfate.
- Comparator Control
- No administration of intravenous magnesium sulfate.
- Main Outcome
- The primary outcome of this systematic review and meta-analysis will be the pain scores recorded after surgery. Measures of effect The authors will extract the data regarding pain scores in each clinical trial. Reported pain scores after surgery, including the timing of pain score assessment, will be analyzed. To pool the overall estimates of the pain scores, we will convert all numeric and visual analog scales to a 0-10 scale in which 0 is no pain and 10 is a severe form of pain.
- Outcome Measure
- Additional Outcome
- The secondary outcomes will be the overall opioid consumption, and time for first rescue analgesia. Measures of effect The opioid consumption will be extracted from each article and converted to a morphine equivalent for comparison using a published conversion factor. The time for the first rescue analgesia will be measured in hours.
- Study Method
- Keyword
- Administration, Intravenous; Humans; Magnesium Sulfate; Pain, Postoperative
- Contact
- Tito D. Tubog [email protected]
- Organisational Affiliation
- Texas Wesleyan University
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-09
- Registration Date
- 2023-09-20
- Anticipated Start Date
- 2023-03-13
- Anticipated Completion Date
- 2023-10-30
- Title Cn
- 硫酸镁对脊柱手术后疼痛的影响
- Title En
- The Effect of Magnesium Sulfate on Postoperative Pain in Spine Surgery
- Bilingual Status
- complete