Meta AnalysisID 7770
硫酸镁与硝苯地平用于早产宫缩抑制的随机对照试验的系统评价与Meta分析
CRD42023422419
Is magnesium sulfate more effective and safe than nifedipine in management of preterm labor in at-risk pregnant women?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7770
- Evidence Id
- 16328
- Core Evidence Id
- 16328
- Source Meta Analysis Id
- 7767
- Herb2 Meta Analysis Id
- HBMA007767
- Crd Id
- CRD42023422419
- Title
- A systematic review and meta-analysis of randomized controlled trials of magnesium sulfate versus nifedipine for tocolysis of preterm labor
- Review Question
- Is magnesium sulfate more effective and safe than nifedipine in management of preterm labor in at-risk pregnant women?
- Study Type Included
- Randomized clinical trials or quasi-randomized clinical trials.
- Condition Being Studied
- Preterm labor is defined as two or more contractions every 5 to 10 minutes apart with cervical change. When birth occurs between 20 weeks of pregnancy and 37 weeks of pregnancy it is called preterm labor. The maternal risk factors include previous abortions, previous preterm labor, short cervix, short interval between pregnancies, previous surgery on the cervix or the uterus, multiple pregnancy, vaginal bleeding, low pregnancy weight, genitourinary tract infection, smoking during pregnancy and drug abuse during pregnancy. Magnesium sulfate in obstetrics can be used as a tocolytic, anticonvulsant for preeclampsia, and is thought to act as fetal neuroprotection. Magnesium sulfate is the most widely used tocolytic, an effective role of it has never been established. However, magnesium sulfate readily crosses the vasculosincytial membrane in the terminal villi of the placenta being transferred from maternal to fetal circulation and can cause respiratory and motor depression of the neonate. In the other hand, nifedipine is a calcium antagonist effective and rather safe alternative tocolytic agent for management of preterm labor. This study aims to evaluate the effectiveness and safety of magnesium sulfate compared to nifedipine for preterm labor.
- Participant
- Pregnant women at 20 to 37 weeks' gestation hospitalized in preterm labor.
- Animal
- Human Disease Modelled
- Intervention
- Intravenous magnesium sulfate.
- Comparator Control
- Oral nifedipine.
- Main Outcome
- Gestational age at delivery. Measures of effect We will present dichotomous outcomes as odds ratios (OR) and 95% confidence intervals (CIs). We will report continuous outcomes as mean differences (MD) and 95% CIs if the outcomes have been measured in the same way across all included trials. In the case that included trials measured continuous outcomes in different ways, we will use the standardized mean difference (SMDs) and 95% CI as the effect measure.
- Outcome Measure
- Additional Outcome
- Pregnancy prolongation of 48 hours or more; pregnancy prolongation of 7 days or more; adverse drug reactions, such as: nausea and vomiting, headache, hypotension, flushing hot flashes, dizziness, dyspnea, tachycardia and chest pain. Measures of effect We will present dichotomous outcomes as odds ratios (OR) and 95% confidence intervals (CIs). We will report continuous outcomes as mean differences (MD) and 95% CIs if the outcomes have been measured in the same way across all included trials. In the case that included trials measured continuous outcomes in different ways, we will use the standardized mean difference (SMDs) and 95% CI as the effect measure.
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Female; Humans; Infant, Newborn; Magnesium Sulfate; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnant Women; Randomized Controlled Trials as Topic; Tocolysis
- Contact
- Amaxsell Souza [email protected]
- Organisational Affiliation
- Federal University of Rio Grande do Norte
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-28
- Registration Date
- 2023-05-09
- Anticipated Start Date
- 2023-04-30
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 硫酸镁与硝苯地平用于早产宫缩抑制的随机对照试验的系统评价与Meta分析
- Title En
- A systematic review and meta-analysis of randomized controlled trials of magnesium sulfate versus nifedipine for tocolysis of preterm labor
- Bilingual Status
- complete