Meta AnalysisID 7750
锂与甲状腺功能减退症：一项系统评价、Meta分析与Meta回归分析
CRD42023448994
Despite the well-established association between lithium and hypothyroidism, there is a paucity of current evidence assessing the prevalence of this adverse drug effect. Furthermore, there is no consensus about clinical
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7750
- Evidence Id
- 16308
- Core Evidence Id
- 16308
- Source Meta Analysis Id
- 7747
- Herb2 Meta Analysis Id
- HBMA007747
- Crd Id
- CRD42023448994
- Title
- Lithium and hypothyroidism: a systematic review, meta-analysis and meta-regression analysis.
- Review Question
- Despite the well-established association between lithium and hypothyroidism, there is a paucity of current evidence assessing the prevalence of this adverse drug effect. Furthermore, there is no consensus about clinical correlates that may influence the development of hypothyroidism in lithium users. Therefore, the aim of this study is to assess the prevalence and clinical correlates of hypothyroidism in individuals undergoing lithium treatment.
- Study Type Included
- observational or interventional, cross-sectional or longitudinal studies, including randomized clinical trials, controlled or uncontrolled cohort studies, and case-control studies.
- Condition Being Studied
- hypothyroidism measured by TSH levels.
- Participant
- we will include studies with participants who used lithium and underwent evaluation of thyroid function by measuring serum TSH levels. There will be no restrictions on the psychiatric diagnosis. We will exclude studies in which the entire initial sample consisted exclusively of patients diagnosed with hypothyroidism.
- Animal
- Human Disease Modelled
- Intervention
- use of lithium.
- Comparator Control
- We will not utilize any comparators for our primary outcome. Additionally, we will calculate the odds ratio for hypothyroidism in patients who received lithium treatment compared to those who did not.
- Main Outcome
- prevalence of hypothyroidism in lithium users. Measures of effect prevalence/ proportion.
- Outcome Measure
- Additional Outcome
- prevalence of hyperparathyroidism in lithium users. Measures of effect prevalence/ proportion.
- Study Method
- Meta-analysis, Systematic review, Other
- Keyword
- Drug-Related Side Effects and Adverse Reactions; Humans; Hypothyroidism; Lithium; Prevalence; Thyroxine
- Contact
- Pedro Kazlauckas Lucas [email protected]
- Organisational Affiliation
- HCPA
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-26
- Registration Date
- 2023-08-06
- Anticipated Start Date
- 2023-08-08
- Anticipated Completion Date
- 2024-12-30
- Title Cn
- 锂与甲状腺功能减退症：一项系统评价、Meta分析与Meta回归分析
- Title En
- Lithium and hypothyroidism: a systematic review, meta-analysis and meta-regression analysis.
- Bilingual Status
- complete