Meta AnalysisID 7749
锂对人类认知的影响：一项系统评价
CRD42023407053
How does lithium impact cognitive functions in human? How does it compare within healthy subjects and different clinical populations?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7749
- Evidence Id
- 16307
- Core Evidence Id
- 16307
- Source Meta Analysis Id
- 7746
- Herb2 Meta Analysis Id
- HBMA007746
- Crd Id
- CRD42023407053
- Title
- The effects of lithium on cognition in humans: a systematic review
- Review Question
- How does lithium impact cognitive functions in human? How does it compare within healthy subjects and different clinical populations?
- Study Type Included
- This review will only include quantitative primary research, and with no limitations on the types of study designs that are eligible for inclusion.
- Condition Being Studied
- This systematic review is focusing on the cognitive outcomes of different cohorts taking lithium.
- Participant
- Inclusion: Healthy subjects not taking lithium, healthy volunteers taking lithium, patients with mild cognitive impairment including amnestic mild cognitive impairment (aMCI) or established dementias, and patients with affective disorders including bipolar disorder, major depressive disorders, and schizoaffective disorders. Patients with other neuropsychiatry conditions will be considered if sufficient. Exclusion: Children/adolescents (under 18 years of age).
- Animal
- Human Disease Modelled
- Intervention
- We will include all interventions using lithium salts in the form of regulated medication or commercial supplement (e.g., lithium carbonate, lithium citrate, lithium orotate). Doses including low-dose lithium (serum lithium level < 0.6 mmol/L) and therapeutic doses (serum lithium level ≧ 0.6 mmol/L) according to NICE prescribing guidelines.
- Comparator Control
- Any data with lithium treatment will be considered including between-subjects comparison (i.e. groups taking lithium compared to not taking lithium, groups taking lithium in different doses, clinical populations taking lithium compared to healthy control group, and lithium monotherapy compared to polytherapy if data is sufficient) and within-subjects (before treatment compared to after treatment). Where possible we will examine effect modifiers e.g., taking lithium with concomitant drugs affecting cognition compared to without, and different treatment durations.
- Main Outcome
- Measures of cognitive function such as attention, memory, planning, and language. Measures of effect If appropriate, the magnitude of an effect will be measured by odds ratio for binary/dichotomous outcomes, Cohen's d for continuous outcomes, and SMD for both binary and continuous outcomes.
- Outcome Measure
- Additional Outcome
- Potential effect modifiers for cognitive function, such as different population, lithium dose, treatment duration, and concomitant drugs used. Measures of effect If appropriate, the magnitude of an effect will be measured by odds ratio for binary/dichotomous outcomes, Cohen's d for continuous outcomes, and SMD for both binary and continuous outcomes.
- Study Method
- Intervention, Narrative synthesis, Systematic review
- Keyword
- Cognition; Healthy Volunteers; Humans; Lithium
- Contact
- Talitha Najmillah Sabtiari [email protected]
- Organisational Affiliation
- Funding Source
- This independent research is supported by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-10
- Registration Date
- 2023-03-10
- Anticipated Start Date
- 2023-03-01
- Anticipated Completion Date
- 2023-08-01
- Title Cn
- 锂对人类认知的影响：一项系统评价
- Title En
- The effects of lithium on cognition in humans: a systematic review
- Bilingual Status
- complete