Meta AnalysisID 7748
补充亮氨酸对活跃个体肌肉增长、力量和恢复的影响：一项随机对照试验的系统评价
CRD42023489418
How does the leucine supplementation impact muscle adaptations of trained adults? How does the leucine supplementation impact exercise performance of trained adults?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7748
- Evidence Id
- 16306
- Core Evidence Id
- 16306
- Source Meta Analysis Id
- 7745
- Herb2 Meta Analysis Id
- HBMA007745
- Crd Id
- CRD42023489418
- Title
- Effects of leucine supplementation on muscle growth, strength, and recovery of active Individuals: a systematic review of randomized controlled trials
- Review Question
- How does the leucine supplementation impact muscle adaptations of trained adults? How does the leucine supplementation impact exercise performance of trained adults?
- Study Type Included
- Included: Randomized controlled trials (RCTs) Only on the English language From all years to date. Leucine supplementation as intervention Intervention period at least one session. Excluded: Unpublished studies (e.g., conference abstracts, trial protocols) Observational studies (including cohort and case-control studies) Animal studies Leucine supplementation along with other short-chain amino acids.
- Condition Being Studied
- It has been suggested that the leucine supplementation and its metabolites may improve the muscle recovery after physical activity. Leucine and its metabolites reduce IL-6, which is a well-known pro-inflammatory cytokine, so that explains its effect post-exercise.
- Participant
- Trained adults (18-40 years old) with leucine supplementation and non-supplemented trained adults. We stated the following exclusion criteria: 1) individuals with any type of supplementation other than leucine, 2) individuals younger than 18 or older than 40 years, 3) pregnant women and 4) individuals with a diagnosis of Non-Communicable Chronic Diseases (NCD).
- Animal
- Human Disease Modelled
- Intervention
- Leucine as only source of supplementation and physical activity.
- Comparator Control
- Non-supplemented trained adults (18-40 years)
- Main Outcome
- Muscle strength: Isometric strength, counter-movement jump height, Muscle growth: Task performance, insulin, lactate, and amino acids concentrations, muscle amino acid concentrations and AKT, mTOR, eEF2 phosphorylation, and S6K1 activity, acid plasma, insulin, and IGF-1 concentrations, IGF-1R, and mTOR phosphorylation and protein-protein interactions. Muscle recovery: Lactate dehydrogenase, CK plasma concentrations and repetition maximum, and pain.
- Outcome Measure
- Additional Outcome
- ND Measures of effect ND
- Study Method
- Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Marco Segura Bujan [email protected]
- Organisational Affiliation
- Universidad de Costa Rica https://www.ucr.ac.cr/
- Funding Source
- This Systematic Review was funded by the University of Cambridge via their program ReachSci: Mini PhD Grant number(s) State the funder, grant or award number and the date of award ND
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Unlikely as this is the first such review for the authors. Systematic reviews have been conducted using BCAAs or other amino acids, but not leucine supplementation alone.
- Published Protocol
- Review Type
- Language
- English
- Country
- Costa Rica
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-04
- Registration Date
- 2023-12-14
- Anticipated Start Date
- 2023-11-17
- Anticipated Completion Date
- 2024-01-31
- Title Cn
- 补充亮氨酸对活跃个体肌肉增长、力量和恢复的影响：一项随机对照试验的系统评价
- Title En
- Effects of leucine supplementation on muscle growth, strength, and recovery of active Individuals: a systematic review of randomized controlled trials
- Bilingual Status
- complete