Meta AnalysisID 7732
血清素、催产素和精氨酸加压素作为自闭症谱系障碍患者攻击行为的生物标志物：系统评价
CRD42023494206
Is there an association between the plasma levels of biological markers (oxytocin, arginine-vasopressin and serotonin) and measures of aggressiveness in individuals with ASD, with the severity of the clinical presentatio
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7732
- Evidence Id
- 16290
- Core Evidence Id
- 16290
- Source Meta Analysis Id
- 7729
- Herb2 Meta Analysis Id
- HBMA007729
- Crd Id
- CRD42023494206
- Title
- Serotonin, oxytocin and arginine vasopressin as biomarkers of aggressive behavior in patients with Autism Spectrum Disorder (ASD): a Systematic Review
- Review Question
- Is there an association between the plasma levels of biological markers (oxytocin, arginine-vasopressin and serotonin) and measures of aggressiveness in individuals with ASD, with the severity of the clinical presentation?
- Study Type Included
- Inclusion criteria: a) original articles that evaluated individuals with Autism Spectrum Disorder, no age restriction, no gender distinction, measures of aggressive behavior and aggressiveness, associating them with the biological markers serotonin, oxytocin and arginine-vasopressin b) articles with all types of methodological studies (articles with randomized studies will be prioritized) c) articles in English, Spanish and Portuguese Exclusion criteria: a) review articles, editorials, errata, notes, book chapters, conference abstracts b) c) articles with animal research c) articles with genetic syndromes d)articles with other biological markers d) articles in languages other than English, Spanish and Portuguese
- Condition Being Studied
- Autism Spectrum Disorder has a prevalence of around 2% of the world population. Symptoms of aggression are present in more than 20% of cases. Dysfunctions involving 5-HT2 receptors (serotonin) in prefrontal cortical regions can result in aggressive behaviors. Oxytocin modulates social behaviors, including expressions of aggression. Single base polymorphisms in Arginine-Vasopressin receptor genes are associated with amygdala activation and deficits in social skills and expression.
- Participant
- Patients diagnosed with Autism Spectrum Disorder (no age limits)
- Animal
- Human Disease Modelled
- Intervention
- Plasma levels of biological markers (oxytocin, arginine-vasopressin, serotonin)
- Comparator Control
- No comparator
- Main Outcome
- Aggressiveness as primary outcome and clinical severity as secondary outcome Measures of effect The risk of bias is associated with the plasma levels of biomarkers assessed alone or together with primary outcome measures (aggressiveness levels - measured by specific scales) and secondary (clinical severity - measured by specific scale)
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Fabio Sato [email protected]
- Organisational Affiliation
- University of Sao Paulo - USP
- Funding Source
- own resorces Grant number(s) State the funder, grant or award number and the date of award own resorces
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-17
- Registration Date
- 2023-12-28
- Anticipated Start Date
- 2023-12-28
- Anticipated Completion Date
- 2024-07-01
- Title Cn
- 血清素、催产素和精氨酸加压素作为自闭症谱系障碍患者攻击行为的生物标志物：系统评价
- Title En
- Serotonin, oxytocin and arginine vasopressin as biomarkers of aggressive behavior in patients with Autism Spectrum Disorder (ASD): a Systematic Review
- Bilingual Status
- complete