Meta AnalysisID 7730
不同剂量精氨酸在压力性损伤伤口愈合中效果的比较：随机试验的系统评价与Meta分析
CRD42023482982
(1)P:"Pressure sore* " OR "Bedsore*" OR "Bed Sore*"OR "Decubitus Ulcer" OR "pressure ulcer" OR "pressure injury");(2)I:("Arginine "OR "Monohydrate DL-Arginine Acetate" OR"L-Isomer Arginine" OR "L-Arginine" OR "Arginine H
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7730
- Evidence Id
- 16288
- Core Evidence Id
- 16288
- Source Meta Analysis Id
- 7727
- Herb2 Meta Analysis Id
- HBMA007727
- Crd Id
- CRD42023482982
- Title
- Comparing the Effectiveness of Various Doses of Arginine in the Healing of Pressure Injury Wounds: A Systematic Review and Meta-Analysis of Randomized Trials
- Review Question
- (1)P:"Pressure sore* " OR "Bedsore*" OR "Bed Sore*"OR "Decubitus Ulcer" OR "pressure ulcer" OR "pressure injury");(2)I:("Arginine "OR "Monohydrate DL-Arginine Acetate" OR"L-Isomer Arginine" OR "L-Arginine" OR "Arginine Hydrochloride");(3)Regular Care;(4)O: "Wound healing rate" OR "wound healing area" OR "wound healing time" OR "severity;(5)S:randomized controlled trial.
- Study Type Included
- Study type: randomized controlled trial (RCT). Exclusion criteria were: studies not published as full-length original papers (e.g., letters, reviews, and case reports).
- Condition Being Studied
- Pressure injury (PI) is a common complaint in bedridden cases. When PI reach deep into the muscles, they take a long time to heal, are painful, and carry the risk of infection, which not only affects quality of life, but also increases medical costs and the financial burden on caregivers. The study suggests that arginine supplementation can significantly improve wound healing, and it is hoped that a systematic review of the literature will confirm its benefits for further application in practice, with the aim of improving wound healing in home PI.
- Participant
- Studies that met the following criteria were eligible for review: Participants: Patients with pressure injuries
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Studies that investigate Arginine, including its various forms such as Monohydrate DL-Arginine Acetate, L-Isomer Arginine, L-Arginine, or Arginine Hydrochloride;Oral supplementation of arginine nutritional supplements.
- Comparator Control
- control group only general protein or routine care nutritional supplements
- Main Outcome
- Research examining wound healing rate, wound healing area, wound healing time, or severity of wounds Measures of effect Effect sizes in the present study were expressed as standardized mean difference (SMD) with 95% confidence intervals (CI), as different assessment scales were used for the same endpoints. If the same instrument or scale was utilized across the studies included in the meta-analysis, the mean deviation was employed as a statistical measure for the analysis.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Nai Ching Chen [email protected]
- Organisational Affiliation
- Chimei Medical Center
- Funding Source
- No funding or sponsorship.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia, China, Taiwan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-11-14
- Registration Date
- 2023-11-26
- Anticipated Start Date
- 2023-10-01
- Anticipated Completion Date
- 2024-02-01
- Title Cn
- 不同剂量精氨酸在压力性损伤伤口愈合中效果的比较：随机试验的系统评价与Meta分析
- Title En
- Comparing the Effectiveness of Various Doses of Arginine in the Healing of Pressure Injury Wounds: A Systematic Review and Meta-Analysis of Randomized Trials
- Bilingual Status
- complete