Meta AnalysisID 7726

氟化银与精氨酸在调节口腔生物膜以管理龋病中的作用比较：系统评价

CRD42023466127

What is the comparative effectiveness of Silver Fluoride vs. Arginine in modifying oral biofilm for caries management and prevention in individuals with dental caries or at risk of developing dental caries? Population (P

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Meta Analysis Id: 7726
Evidence Id: 16284
Core Evidence Id: 16284
Source Meta Analysis Id: 7723
Herb2 Meta Analysis Id: HBMA007723
Crd Id: CRD42023466127
Title: Role of Silver Fluoride Compared to Arginine in Modifying Oral Biofilm for Caries Management : A Systematic Review
Review Question: What is the comparative effectiveness of Silver Fluoride vs. Arginine in modifying oral biofilm for caries management and prevention in individuals with dental caries or at risk of developing dental caries? Population (P): Individuals with dental caries or at risk of developing dental caries. Intervention (I): Silver fluoride treatment. Comparator (C): Arginine treatment. Outcome (O): Modification of oral biofilm for caries management and prevention.
Study Type Included: Types of Study to Be Included: Inclusion Criteria: Randomized controlled trials (RCTs). Non-randomized controlled trials. Observational cohort studies. Cross-sectional studies. Case-control studies. Clinical trials. Systematic reviews that meet the inclusion criteria and provide relevant data. Exclusion Criteria: Case reports and case series. Animal studies without clear relevance to human oral health. Studies without available full-text articles. Review articles without primary data. Studies lacking essential information on interventions, comparators, or outcomes. Studies with insufficient data for analysis.
Condition Being Studied: The systematic review will focus on the role of silver fluoride and arginine in modifying oral biofilms for caries management and prevention. It will examine studies related to the use of these agents in controlling dental caries and their impact on oral biofilm composition and caries prevention.
Participant: Participants/Population: Inclusion Criteria: Human participants of all age groups. Participants with existing dental caries or at risk of developing dental caries. Studies conducted on individuals with oral biofilm-related issues. Studies involving the use of silver fluoride or arginine-based products for oral care. Exclusion Criteria: Studies on participants not related to dental caries or oral biofilm modification. Studies using interventions other than silver fluoride or arginine-based products.
Animal
Human Disease Modelled
Intervention: Intervention(s) and Exposure(s): Inclusion Criteria: Studies comparing the use of silver fluoride to arginine for caries management, control or prevention. Studies investigating the use of silver fluoride or arginine-based products for oral biofilm modification. Studies examining the application of silver fluoride or arginine-based products in the context of dental caries prevention, control, or management. Studies assessing the effectiveness and safety of silver fluoride or arginine-based interventions. Exclusion Criteria: Studies not involving the use of silver fluoride or arginine-based products. Studies on interventions unrelated to dental caries or oral biofilm modification.
Comparator Control: Comparator(s)/Control: Inclusion Criteria: Studies comparing the use of silver fluoride to arginine for caries management, control or prevention. Studies comparing the use of silver fluoride to a placebo, or standard care. Studies comparing the use of arginine-based products to a placebo, or standard care. Studies involving control groups receiving no intervention or standard oral hygiene measures. Exclusion Criteria: Studies not including a comparator or control group. Studies where the control group receives interventions other than those mentioned in the inclusion criteria. Studies with inadequate information regarding the comparator or control group.
Main Outcome: Dental Caries Prevention: The primary outcome is the prevention of dental caries through the modification of oral biofilms using silver fluoride and arginine. This outcome will be assessed by measuring the incidence and severity of new carious lesions (cavities) in individuals who received these interventions. The outcome will be defined based on clinical examinations, radiographic assessments, or other validated diagnostic criteria used in the included studies. Oral Biofilm Modification: The review will evaluate the effectiveness of silver fluoride and arginine in modifying oral biofilms. This will include assessing changes in biofilm composition, reduction in pathogenic bacterial populations, and alteration of biofilm structure. The outcome will be defined based on microbiological analyses, biofilm imaging, or other relevant measurements used in the included studies. Safety and Adverse Events: The safety of silver fluoride and arginine interventions will be a key outcome. Any adverse events or side effects associated with these interventions will be assessed. This outcome will be defined by the occurrence and nature of adverse events reported in the included studies. Measures of effect Measures of Effect: Dental Caries Prevention: The effect measure for the primary outcome, dental caries prevention, will be reported as the Relative Risk (RR) or Risk Ratio (RR). This measure will quantify the difference in the incidence of new carious lesions between the groups receiving silver fluoride and arginine interventions and the control groups. If feasible, the Number Needed to Treat (NNT) may also be calculated to express the clinical significance of the interventions. Oral Biofilm Modification: The effect of silver fluoride and arginine on oral biofilm modification will be assessed using mean differences (MD) or standardized mean differences (SMD) if outcomes are measured on different scales across studies. This will provide information about the magnitude of change in biofilm composition, bacterial populations, or biofilm structure. Safety and Adverse Events: The effect measure for safety outcomes will be Risk Ratio (RR) or Odds Ratio (OR) if adverse events are binary outcomes. The measure will express the risk of experiencing adverse events associated with silver fluoride and arginine interventions compared to control groups.
Outcome Measure
Additional Outcome: Microbial Composition : Changes in the microbial composition of oral biofilms will be assessed as an additional outcome. This will include the identification and quantification of specific bacteria or microbial groups, with measures such as relative abundance, counts, or proportions. Biofilm Structure: Alterations in biofilm structure will be considered, including biofilm thickness, density, and architecture. These outcomes will be assessed using measures such as mean thickness, surface coverage, or structural indices. Secondary Caries: The occurrence of secondary caries (caries that develop adjacent to existing restorations) will be examined as an additional outcome. This will involve assessing the incidence and severity of secondary carious lesions. Long-term Effects: The long-term effects of silver fluoride and arginine interventions on oral health will be considered. This may involve assessing outcomes such as caries incidence, biofilm modification, and microbial composition over extended follow-up periods. Measures of effect Measures of Effect for Additional Outcomes: Microbial Composition: The effect measure for changes in microbial composition will typically involve relative abundance or proportion of specific microbial taxa before and after the interventions. This may be expressed as odds ratios, risk ratios, or relative risks for specific bacteria or microbial groups. Biofilm Structure: Changes in biofilm structure, such as thickness or density, can be quantified using measures like mean difference, percentage change, or risk difference, comparing biofilm characteristics before and after the interventions. Secondary Caries: The occurrence of secondary caries can be assessed using relative risks, odds ratios, or risk differences comparing the incidence of secondary carious lesions in groups receiving silver fluoride and arginine interventions to control groups. Long-term Effects: Long-term effects may be measured using relative risks, odds ratios, or risk differences for outcomes such as caries incidence, microbial composition, or biofilm structure over extended follow-up periods.
Study Method: Systematic review
Keyword: MeSH headings have not been applied to this record
Contact: Nirmala Chandrasekaran [email protected]
Organisational Affiliation: Ragas Dental College and Hospital https:rdc.ac.in
Funding Source
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: India
Review Stage: Review Ongoing
First Submission Date: 2023-09-23
Registration Date: 2023-10-06
Anticipated Start Date: 2023-10-22
Anticipated Completion Date: 2024-03-22
Title Cn: 氟化银与精氨酸在调节口腔生物膜以管理龋病中的作用比较：系统评价
Title En: Role of Silver Fluoride Compared to Arginine in Modifying Oral Biofilm for Caries Management : A Systematic Review
Bilingual Status: complete