Meta AnalysisID 7723
膳食补充剂减轻空气污染毒性对心肺影响的临床研究：一项系统评价
CRD42023440510
Do dietary supplementations mitigate the cardiopulmonary effects of air pollution toxicity?
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Record Fields
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- Meta Analysis Id
- 7723
- Evidence Id
- 16281
- Core Evidence Id
- 16281
- Source Meta Analysis Id
- 7718
- Herb2 Meta Analysis Id
- HBMA007718
- Crd Id
- CRD42023440510
- Title
- Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials
- Review Question
- Do dietary supplementations mitigate the cardiopulmonary effects of air pollution toxicity?
- Study Type Included
- clinical trials with parallel or crossover design.
- Condition Being Studied
- Air pollution is a complex environmental issue that exerts significant impacts on human populations worldwide. With the increasing industrialization and urbanization, the release of various pollutants into the atmosphere has reached alarming levels, necessitating scientific scrutiny and comprehensive understanding. Air pollution comprises a diverse array of harmful substances, such as particulate matter, nitrogen oxides, sulfur dioxide, volatile organic compounds, and heavy metals. Upon inhalation, these pollutants can penetrate deep into the respiratory system, leading to a range of adverse health effects. Moreover, air pollution has been associated with cardiovascular diseases, including hypertension which can contribute to increased morbidity and mortality rates. Given the substantial burden air pollution places on public health, the main aim of this systematic review is to assess whether different dietary interventions could mitigate the cardiopulmonary effects of air pollution toxicity.
- Participant
- Inclusion: Healthy male and female individuals who are exposed to air pollutants (including particulate matter (PM2.5, PM10), Ozone (O3), NO2, SO2, house dust mite). Individuals with underlying allergy or asthma will also be included. Exclusion: Patients with established cardiac disease, including a history of myocardial infarction or heart failure will be excluded. Moreover, patients with established lung disorders, including COPD and fibrosis will be excluded. Pregnant or breastfeeding individuals will be excluded as well.
- Animal
- Human Disease Modelled
- Intervention
- Interventions will encompass dietary supplementations including vitamin C, combination of vitamin C and vitamin E, L-arginine, Fish Oil (n-3 PUFA), Olive Oil, Sulforaphane, n-acetylcysteine (NAC).
- Comparator Control
- Placebo or control group.
- Main Outcome
- Primary outcomes of interest will be changes in systolic and diastolic blood pressure, blood lipid profile (triglyceride, total cholesterol, very low-density lipoprotein cholesterol (VLDL), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL)), flow-mediated vasodilation of brachial artery, heart rate variability, spirometric indices and induced sputum markers (macrophage, polymorphonuclear neutrophil (PMN), eosinophil). Measures of effect Mean difference and standard deviation (SD) of outcomes
- Outcome Measure
- Additional Outcome
- None. Measures of effect None.
- Study Method
- Systematic review
- Keyword
- Air Pollutants; Air Pollution; Dietary Supplements; Heart; Humans
- Contact
- Mehran Ilaghi [email protected]
- Organisational Affiliation
- Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-28
- Registration Date
- 2023-07-10
- Anticipated Start Date
- 2023-01-29
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 膳食补充剂减轻空气污染毒性对心肺影响的临床研究：一项系统评价
- Title En
- Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials
- Bilingual Status
- complete