Meta AnalysisID 7720
血管加压素受体激动剂在失血性休克复苏中的作用：临床前与临床研究的系统评价与Meta分析
CRD42023422429
What are the effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock?
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Record Fields
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- Meta Analysis Id
- 7720
- Evidence Id
- 16278
- Core Evidence Id
- 16278
- Source Meta Analysis Id
- 7715
- Herb2 Meta Analysis Id
- HBMA007715
- Crd Id
- CRD42023422429
- Title
- Effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock: A systematic review and meta-analysis of preclinical and clinical studies
- Review Question
- What are the effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock?
- Study Type Included
- Studies included will be preclinical (animal) and clinical (randomized and non-randomized controlled trials, comparative studies, cohort studies, validation studies, observational studies). Exclusion criteria will include review articles, case studies, and non-English literature.
- Condition Being Studied
- Approximately 30% of deaths following trauma can be attributed to hemorrhagic shock. The early phase of hemorrhagic shock is characterized by a vasoconstrictive response, but if it is left untreated it can lead to cardiovascular failure and vasodilation that does not respond to conventional resuscitation strategies. Small volume resuscitation may be useful during early phases of uncontrolled bleeding and vasopressors may be required to maintain tissue perfusion where fluid resuscitation itself does not achieve the expected goal. With prolonged hypotension, however, endogenous vasopressin levels are depleted, leading to vasodilatation and hypoperfusion of end-organs. Also, vasopressin is more responsive to vascular hyporeactivity in acidotic environments compared with adrenergic agents. Therefore, vasopressin receptor agonists may be helpful in maintaining perfusion pressure and may improve outcome after hemorrhagic shock. This study will investigate the effects of vasopressin receptor agonists during the in-hospital resuscitation of hemorrhagic shock. This will include preclinical and clinical studies.
- Participant
- Patients and animal models with hemorrhagic shock
- Animal
- Human Disease Modelled
- Intervention
- Administration of vasopressin receptor agonist during the in-hospital resuscitation of hemorrhagic shock.
- Comparator Control
- Patients or animals not treated with vasopressin receptor agonists.
- Main Outcome
- PRECLINICAL STUDIES Relationship between the use of vasopressin receptor agonists and hemodynamic parameters during the resuscitation of hemorrhagic shock. * Measures of effect During resuscitation. Mortality * Measures of effect Within 24 hours after resuscitation. CLINICAL STUDIES Relationship between the use of vasopressin receptor agonists and hemodynamic parameters during the resuscitation of hemorrhagic shock. * Measures of effect During resuscitation. Mortality at * Measures of effect At hospital discharge, at 30 days, at 90 days, and at 1 year.
- Outcome Measure
- Additional Outcome
- PRECLINICAL STUDIES Association of vasopressin receptor agonists with amount of administered fluids, coagulopathy, end-organ damage, multiple organ failure. * Measures of effect During the experiment and at follow-up. CLINICAL STUDIES Association of vasopressin receptor agonists with amount of administered fluids, coagulopathy, end-organ damage, multiple organ failure, days of mechanical ventilation, intensive care unit (ICU) length of stay, and hospital length of stay. * Measures of effect During hospitalization.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Personality; Receptors, Vasopressin; Resuscitation; Shock, Hemorrhagic
- Contact
- Athanasios Chalkias [email protected]
- Organisational Affiliation
- University of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Greece
- Review Stage
- Review Completed not published
- First Submission Date
- 2023-04-28
- Registration Date
- 2023-05-09
- Anticipated Start Date
- 2023-05-07
- Anticipated Completion Date
- 2023-06-20
- Title Cn
- 血管加压素受体激动剂在失血性休克复苏中的作用：临床前与临床研究的系统评价与Meta分析
- Title En
- Effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock: A systematic review and meta-analysis of preclinical and clinical studies
- Bilingual Status
- complete