Meta AnalysisID 7719
精氨酸补充对危重症患者的影响：一项系统评价
CRD42023420750
The impact of arginine administration in critically ill patients on clinical outcomes, such as survival and ICU length of stay, will be studied and used to inform clinical practice.
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Record Fields
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- Meta Analysis Id
- 7719
- Evidence Id
- 16277
- Core Evidence Id
- 16277
- Source Meta Analysis Id
- 7714
- Herb2 Meta Analysis Id
- HBMA007714
- Crd Id
- CRD42023420750
- Title
- Effects of arginine supplementation in critically ill patients: a systematic review
- Review Question
- The impact of arginine administration in critically ill patients on clinical outcomes, such as survival and ICU length of stay, will be studied and used to inform clinical practice.
- Study Type Included
- Studies using RCTs will be conducted Exclusion criteria: Exclusion criteria shall be case reports, , conference proceedings, randomized crossover trials, cluster randomized trials and quasi-experiment trials. Studies for which full text is not available will be excluded. Articles not written in English and Japanese.
- Condition Being Studied
- The subjects of this study will be critically ill patients. Critically ill patients are defined as 1) patients admitted to the ICU for intensive care, 2) patients treated in ICU-like facilities for the following serious medical conditions ⅰ)acute respiratory distress syndrome, ⅱ) major trauma, ⅲ) severe burns, ⅳ) multiple organ failure, ⅴ) septic shock, and ⅵ) severe acute pancreatitis, ⅶ) etc. Q1. mortality rate with arginine administration, Q2. length of ICU stay, Q3. incidence of infection, Q4. duration of ventilation, Q5. physical function assessment (including ADL and QOL) at discharge or thereafter up to 1 year after discharge (BI, FIM, muscle strength [grip strength, MRC-sum score], SPPB, 6-minute walk distance, SF-36 /8, EQ5D5L), Q6. changes in muscle mass during hospitalization or after discharge (assessed using anthropometry, echo, CT, and anthropometry), Q7. all adverse events will be examined.
- Participant
- The subjects of this study will be critically ill patients. Critically ill patients are defined as 1) patients admitted to the ICU for intensive care, 2) patients treated in ICU-like facilities for the following serious medical conditions ⅰ)acute respiratory distress syndrome, ⅱ) major trauma, ⅲ) severe burns, ⅳ) multiple organ failure, ⅴ) septic shock, and ⅵ) severe acute pancreatitis, ⅶ) etc
- Animal
- Human Disease Modelled
- Intervention
- This study will analyze studies in which patients with severe disease were treated with arginine-rich preparations.
- Comparator Control
- Analyze studies in which placebo or standard composition nutritional supplements were administered.
- Main Outcome
- 1. mortality rate with arginine administration, 2. length of ICU stay 3. incidence of infection 4. duration of ventilation 5. physical function assessment (including ADL and QOL) at discharge or thereafter up to 1 year after discharge (BI, FIM, muscle strength [grip strength, MRC-sum score], SPPB, 6-minute walk distance, SF-36 /8, EQ5D5L) 6. changes in muscle mass during hospitalization or after discharge (assessed using anthropometry, echo, CT, and anthropometry) 7. all adverse events will be examined. Measures of effect Calculating relative risk
- Outcome Measure
- Additional Outcome
- none Measures of effect none
- Study Method
- Keyword
- Arginine; Critical Illness; Dietary Supplements; Humans; Intensive Care Units; Length of Stay
- Contact
- Masayuki Kaku [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Japanese
- Country
- Japan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-23
- Registration Date
- 2023-05-04
- Anticipated Start Date
- 2023-04-29
- Anticipated Completion Date
- 2025-04-29
- Title Cn
- 精氨酸补充对危重症患者的影响：一项系统评价
- Title En
- Effects of arginine supplementation in critically ill patients: a systematic review
- Bilingual Status
- complete