Meta AnalysisID 7714
血管活性药物治疗间质性肺疾病相关肺动脉高压：一项系统评价
CRD42023457482
The aim of this systematic review is to explore clinical efficacy of vasoactive therapy in patients with PH secondary to ILD. Interventional randomized controlled trials (RCTs) comparing vasoactive drugs vs placebo and s
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7714
- Evidence Id
- 16272
- Core Evidence Id
- 16272
- Source Meta Analysis Id
- 7710
- Herb2 Meta Analysis Id
- HBMA007710
- Crd Id
- CRD42023457482
- Title
- Vasoactive drugs for the treatment of pulmonary hypertension associated with interstitial lung diseases: a systematic review
- Review Question
- The aim of this systematic review is to explore clinical efficacy of vasoactive therapy in patients with PH secondary to ILD. Interventional randomized controlled trials (RCTs) comparing vasoactive drugs vs placebo and secondary analysis of the above-mentioned trials are considered. The primary outcome of this systematic review is clinical efficacy, defined by any measurable effect in hemodynamics, clinical status, pulmonary function tests, performance in activities, progression in pulmonary or vascular disease.
- Study Type Included
- Randomized control trials
- Condition Being Studied
- Pulmonary hypertension
- Participant
- Adult patients with pulmonary hypertension secondary to interstitial lung diseases
- Animal
- Human Disease Modelled
- Intervention
- Interventions with 10 different vasoactive drugs are considered (riociguat, sildenafil, tadalafil, bosentan, macitentan, ambrisentan, treprostinil, iloprost, selexipag, isosorbide dinitrate).
- Comparator Control
- Placebo
- Main Outcome
- Clinical efficacy, defined by any measurable effect in hemodynamics, clinical status, pulmonary function tests, performance in activities, progression in pulmonary or vascular disease. Measures of effect Clinical efficacy, defined by any measurable effect in hemodynamics, clinical status, pulmonary function tests, performance in activities, progression in pulmonary or vascular disease.
- Outcome Measure
- Additional Outcome
- Not appliacable
- Study Method
- Systematic review
- Keyword
- Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, Interstitial; Randomized Controlled Trials as Topic; Treatment Outcome
- Contact
- Francesco Amati [email protected]
- Organisational Affiliation
- Humanitas University, Via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Italy
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-24
- Registration Date
- 2023-09-04
- Anticipated Start Date
- 2023-08-24
- Anticipated Completion Date
- 2023-09-22
- Title Cn
- 血管活性药物治疗间质性肺疾病相关肺动脉高压：一项系统评价
- Title En
- Vasoactive drugs for the treatment of pulmonary hypertension associated with interstitial lung diseases: a systematic review
- Bilingual Status
- complete