Meta AnalysisID 7703
宫颈环扎术、吲哚美辛与抗生素在双胎妊娠中的作用
CRD42023401099
Objective: To determine the role of cervical cerclage, indomethacin and antibiotics in reducing the risk of (spontaneous spreterm birth) sPTB in twin pregnancies. Study design: MEDLINE, Embase, CINAHL and Cochrane databa
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7703
- Evidence Id
- 16261
- Core Evidence Id
- 16261
- Source Meta Analysis Id
- 7697
- Herb2 Meta Analysis Id
- HBMA007697
- Crd Id
- CRD42023401099
- Title
- Role of cervical cerclage, indomethacin and antibiotics in twin pregnancies
- Review Question
- Objective: To determine the role of cervical cerclage, indomethacin and antibiotics in reducing the risk of (spontaneous spreterm birth) sPTB in twin pregnancies. Study design: MEDLINE, Embase, CINAHL and Cochrane databases were explored. The inclusion criteria were studies in which twin pregnancies were randomized to an intervention for the prevention of PTB (cervical cerclage, indomethacin and antibiotics, or any combination of these) or to a control group (e.g. placebo or treatment as usual). Interventions of interest were either cerclage(McDonald or Shirodkar), indomethacin or antibiotics. The primary outcome was gestational age (GA) at delivery. Both primary and secondary outcomes were explored in an unselected population of twin pregnancies and in women at higher risk of PTB (defined as those with or any combination of these) or to a control group (e.g. placebo or treatment as usual).). Case reports, reviews, meta-analyses, studies without controlled groups, and studies lacking outcomes of interest or necessary data were excluded.
- Study Type Included
- No limit of types of study
- Condition Being Studied
- obstetrics
- Participant
- twin pregnancy with cervical length<25mm or cervical dilation>1 cm in mid-term gestation
- Animal
- Human Disease Modelled
- Intervention
- cervical cerclage, indomethacin, antibiotics or any combination of these
- Comparator Control
- a control group (e.g. placebo or treatment as usual).
- Main Outcome
- The primary outcome was gestational age (GA) at delivery. Measures of effect odds ratios,
- Outcome Measure
- Additional Outcome
- The secondary outcomes were pregnancy latency, the rate of sPTB at <28, <30, <32, <34weeks, and neonatal outcomes. Measures of effect odds ratios
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Anti-Bacterial Agents; Female; Gestational Age; Humans; Indomethacin; MEDLINE; Pregnancy; Pregnancy, Twin
- Contact
- Liping Qiu [email protected]
- Organisational Affiliation
- Huzhou Maternity ＆ Child Health Care Hospital
- Funding Source
- 4+X Clinical Research Project of Women's Hospital School of Medicine, Zhejiang University Grant number(s) State the funder, grant or award number and the date of award ZDFY2022-4X204
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-02-19
- Registration Date
- 2023-03-02
- Anticipated Start Date
- 2023-01-01
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 宫颈环扎术、吲哚美辛与抗生素在双胎妊娠中的作用
- Title En
- Role of cervical cerclage, indomethacin and antibiotics in twin pregnancies
- Bilingual Status
- complete