Meta AnalysisID 7698
薄荷油在胃肠内镜检查中的有效性和安全性评估：随机临床试验的系统评价与Meta分析
CRD42023430941
Is peppermint oil an effective and safe agent to improve the quality of gastrointestinal endoscopy in adults compared to a placebo or standard agents?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7698
- Evidence Id
- 16256
- Core Evidence Id
- 16256
- Source Meta Analysis Id
- 7693
- Herb2 Meta Analysis Id
- HBMA007693
- Crd Id
- CRD42023430941
- Title
- Assessment of efficacy and safety of peppermint oil during gastrointestinal endoscopy: A systematic review and meta-analysis of randomized clinical trials
- Review Question
- Is peppermint oil an effective and safe agent to improve the quality of gastrointestinal endoscopy in adults compared to a placebo or standard agents?
- Study Type Included
- Randomized controlled clinical trials will be included.
- Condition Being Studied
- Gastrointestinal (GI) endoscopy is a commonly used diagnostic tool for detecting gastrointestinal lesions, e.g., adenoma and erosions. The inhibition of gastric peristalsis can increase the chances of detecting small lesions during GI endoscopy, resulting in a more accurate diagnosis. However, traditional antispasmodic agents, such as hyoscine-N-butylbromide and glucagon, are often associated with adverse events and may not be suitable for use in elderly patients with comorbidities. One alternative option could be peppermint oil, a well-known spasmolytic agent traditionally used to treat irritable bowel syndrome (IBS). Menthol, the main ingredient of peppermint oil, relaxes GI smooth muscles, acting locally as a Ca2+ channel antagonist. Although peppermint is a commonly used medicinal herb, its clinical efficacy and safety as an alternative antispasmodic agent during endoscopy have not been investigated extensively.
- Participant
- Adult patients undergoing upper or lower gastrointestinal endoscopy, endoscopic retrograde cholangiopancreatography or endoscopic ultrasound
- Animal
- Human Disease Modelled
- Intervention
- Peppermint oil or it’s active ingredient L-menthol, as a standalone or an add-on treatment
- Comparator Control
- Placebo or standard antispasmodic agent
- Main Outcome
- The quality of endoscopy measured by the adenoma detection rate. Measures of effect For continuous variables we will calculate mean differences (MDs) with 95% confidence intervals (CIs) and standardized mean differences (SMDs) with 95% CIs. For categorical variables we will calculate odds ratios (ORs) with 95% CIs.
- Outcome Measure
- Additional Outcome
- tolerability (pain score) severity of peristalsis safety (adverse events) procedure duration ease of the intragastric examination adverse drug reactions duration of sustained response pharmacokinetic parameters mucosal change rate contraction ratio hemodynamic changes visibility scores volume for mucosal cleansing willingness to repeat colonoscopy occurrence of gastric peristalsis per minute Measures of effect For continuous variables we will calculate mean differences (MDs) with 95% confidence intervals (CIs) and standardized mean differences (SMDs) with 95% CIs. For categorical variables we will calculate odds ratios (ORs) with 95% CIs.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Adult; Endoscopy, Gastrointestinal; Humans; Mentha piperita; Randomized Controlled Trials as Topic
- Contact
- Dorottya Gergo [email protected]
- Organisational Affiliation
- Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Faculty of Pharmacy, Department of Pharmacognosy, Semmelweis University, Budapest, Hungary https://tm-centre.org/ https://semmelweis.hu/farmakognozia/en/department-of-pharmacognosy/
- Funding Source
- Centre for Translational Medicine, Semmelweis University
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-30
- Registration Date
- 2023-06-10
- Anticipated Start Date
- 2023-05-31
- Anticipated Completion Date
- 2023-11-30
- Title Cn
- 薄荷油在胃肠内镜检查中的有效性和安全性评估：随机临床试验的系统评价与Meta分析
- Title En
- Assessment of efficacy and safety of peppermint oil during gastrointestinal endoscopy: A systematic review and meta-analysis of randomized clinical trials
- Bilingual Status
- complete