Meta AnalysisID 7697
汞暴露是否损害男性生殖参数？一项系统评价
CRD42023413975
What are the effects of mercury exposure on male reproductive parameters of murine models? With an emphasis on histology and oxidative stress Context and rationale Mercury is a heavy metal, which can be found in forms th
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7697
- Evidence Id
- 16255
- Core Evidence Id
- 16255
- Source Meta Analysis Id
- 7692
- Herb2 Meta Analysis Id
- HBMA007692
- Crd Id
- CRD42023413975
- Title
- Can exposure to mercury compromise male reproductive parameters? A systematic review.
- Review Question
- What are the effects of mercury exposure on male reproductive parameters of murine models? With an emphasis on histology and oxidative stress Context and rationale Mercury is a heavy metal, which can be found in forms that have a considerable diversity of toxicological properties. Prolonged exposure to different mercury compounds, in addition to causing toxic effects on organs such as the skin, can also have harmful effects on different systems, such as the urinary, respiratory, gastrointestinal and nervous systems. Furthermore, as well as neurological and motor damage caused by mercury, there are also reports of damage to the male reproductive system. Therefore, considering the potential of mercury to cause changes to the male reproductive system, this study aims to gather and examine experimental evidence on the action of mercury (or mercury compounds) on the male reproductive system of murine models, thus potentially having clinical relevance. and scientific when considering the relationship between exposure to mercury and male reproductive dysfunction.
- Study Type Included
- Inclusion criteria: Experimental study. Exclusion criteria: In vitro experimental studies; non-experimental studies (e.g. review studies, conference abstracts, book chapters, letters to the editor, comments and editorials, case studies...)
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: The population of this work must be composed of male murine models. Exclusion criteria: Animal species other than murine models; females, sexually immature animals and castrated animals.
- Human Disease Modelled
- Male reproductive disorders, testicular and epididymal histopathology, male infertility, sperm dysfunction.
- Intervention
- Inclusion criteria: Study animals must be treated with any type of mercury (organic, inorganic or elemental mercury). And there is no restriction regarding the duration of the exposure period, doses used, number of exposures and route of administration. Exclusion criteria: Absence of mercury treatment.
- Comparator Control
- Inclusion criteria: Studies must contain a control group (without treatment with mercury compounds) and treatment (treated with mercury compounds). Exclusion criteria: Absence of control group and/or treatment group with mercury compounds.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Studies evaluating the effects of treatment with mercury compounds on histomorphology, histopathology and oxidative stress in the testicles or epididymis and sperm analysis in a murine model. Exclusion criteria: Studies that do not evaluate the testis, epididymis or sperm of murine models treated with mercury compounds.
- Additional Outcome
- Study Method
- Keyword
- Animals; Humans; Male; Mercury; Mercury Compounds; Metals, Heavy; Mice; Oxidative Stress; Reproduction
- Contact
- Izabela Lopes [email protected]
- Organisational Affiliation
- Universidade Federal de Viçosa https://www.ufv.br/
- Funding Source
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Other Selection Criteria
- Inclusion criteria: only studies published in English.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-18
- Registration Date
- 2023-10-11
- Anticipated Start Date
- 2022-10-12
- Anticipated Completion Date
- 2023-12-12
- Title Cn
- 汞暴露是否损害男性生殖参数？一项系统评价
- Title En
- Can exposure to mercury compromise male reproductive parameters? A systematic review.
- Bilingual Status
- complete