Meta AnalysisID 7683
儿科人群血管通路相关血栓形成：一项系统评价与Meta分析
CRD42023434090
Is there an efficacy of antithrombotic prophylaxis for the prevention of catheter-related thrombotic events in the pediatric population?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7683
- Evidence Id
- 16241
- Core Evidence Id
- 16241
- Source Meta Analysis Id
- 7677
- Herb2 Meta Analysis Id
- HBMA007677
- Crd Id
- CRD42023434090
- Title
- Vascular access-related thrombosis in the pediatric population: a systematic review and meta-analysis
- Review Question
- Is there an efficacy of antithrombotic prophylaxis for the prevention of catheter-related thrombotic events in the pediatric population?
- Study Type Included
- Inclusion criteria: - Randomized controlled trials and cohort studies. - full article written in English Exclusion criteria: - Comments, editorials, brief reports, case-control studies - Original articles on CVC bonded with heparin, treatment of thrombosis, and general management of the CVCs
- Condition Being Studied
- Thrombosis risk factors in children are multifactorial; both patient-related and catheter-related. Clinical conditions associated with increased thrombotic risk include; heart disease, vascular disease, cancer, metabolic and /or genetic disorders, kidney disease, neurological illness, infections, trauma, surgery, gastroenteric abnormalities, and thrombophilic conditions. The majority of these children are admitted to Intensive care Units (Pediatric, Neonatal, Cardiac). Although the illnesses might differ among all these patients, 80% of VTE events are associated with a . catheter-related risk factors including choice of device insertion techniques,, vein-to-catheter ratio, tip location, stabilization, and management. Asymptomatic VTE are frequently underdiagnosed in children and often detected while performing routine controls.
- Participant
- Pediatric population including neonates Inclusion criteria: - age between 0 -18 years - any type of central-venous catheter - any clinical condition (acute or chronic) Exclusion criteria: - age more or equal than 18 years
- Animal
- Human Disease Modelled
- Intervention
- Pharmacological prophylaxis of catheter related thrombosis defined as the use of unfractioned heparin or low molecular weight heparin.
- Comparator Control
- Comparator: Placebo or no antithrombotic prophylaxis. Control group: pediatric patients with a venous catheter that was managed without pharmacologic prophylaxis with heparin
- Main Outcome
- This review aim to evalute the risk proportion of any thrombotic event that occurred in the treatment group (i.e. antithrombotic prophylaxis) compared to th eproportion of the thrombotic event occurred in the control group (i.e. without antithrombotic prophylaxis). Thrombotic event will be defined as any objectively diagnosed thrombosis. Measures of effect Risk ratio and relative 95% confidence interval
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Catheters; Child; Fibrinolytic Agents; Humans; Thrombosis
- Contact
- Maria Abbattista [email protected]
- Organisational Affiliation
- Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinio
- Funding Source
- Italian Ministry of Health – Bando Ricerca Corrente 2023
- Other Selection Criteria
- Final Publication
- Same Topic Review
- An earlier review in 2015 addressed our topic, but it included papers published before 2000, which are no longer reflective of the current clinical practice. (Mahajerin et al. Hospital-associated venous thromboembolism in pediatrics: a systematic review and meta-analysis of risk factors and risk assessment models. Haematologica. 2015)
- Published Protocol
- Review Type
- Language
- English
- Country
- Italy
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-03
- Registration Date
- 2023-08-14
- Anticipated Start Date
- 2023-05-01
- Anticipated Completion Date
- 2023-09-30
- Title Cn
- 儿科人群血管通路相关血栓形成：一项系统评价与Meta分析
- Title En
- Vascular access-related thrombosis in the pediatric population: a systematic review and meta-analysis
- Bilingual Status
- complete