Meta AnalysisID 7667
获得性唇部色素沉着的治疗：一项系统评价与Meta分析
CRD42023403839
To compare intervention modalities for acquired lip hyperpigmentation in terms of efficacy, safety, side effects, complications, and patient's satisfaction.
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Record Fields
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- Meta Analysis Id
- 7667
- Evidence Id
- 16225
- Core Evidence Id
- 16225
- Source Meta Analysis Id
- 7662
- Herb2 Meta Analysis Id
- HBMA007662
- Crd Id
- CRD42023403839
- Title
- Acquired Lip Hyperpigmentation Treatments: a systematic review and meta analysis
- Review Question
- To compare intervention modalities for acquired lip hyperpigmentation in terms of efficacy, safety, side effects, complications, and patient's satisfaction.
- Study Type Included
- Inclusion: ● Participants aged 18 years or older ● Acquired hyperpigmentation of non-hair bearing, non-cutaneous (mucosal and vermilion) lips including physiological, ethnic, idiopathic hyperpigmentation and diffuse or focal appearance with moderate dark patches on the surface Exclusion: ● Cases of hair-bearing lip hyperpigmentation, ● Cases of cutaneous lip pigmentation ● Cases of congenital lip pigmentation, ● Patients with focal hyperpigmented lesions on the lips (labial melanotic macule, simple lentigines, solar lentigines, melanocytic nevus, pigmented seborrheic keratosis, pigmented Bowen's disease, squamous cell carcinoma, melanoma) ● Patients with multiple diffuse hyperpigmented lesions and/or systemic involvement (lentiginosis syndrome, endocrine/metabolic disorders, heavy metal toxicity, HIV infection) ● Cases of lip hyperpigmentation caused by lip tattooing/augmentation ● Patients with active inflammatory lesions on the lips ● Case report, case series, review articles including systematic reviews and meta-analyses
- Condition Being Studied
- To deliver a meticulous summary of all interventions conducted to address acquired lip pigmentation.
- Participant
- All patients at risk of acquired mucosal lip pigmentation who underwent treatments.
- Animal
- Human Disease Modelled
- Intervention
- ○ Topical treatment ■ Hydroquinone ■ Monobenzyl Ether of Hydroquinone ■ Triple combination treatment with hydroquinone, retinoid and a steroid, ■ Retinoids ■ Chemical peels ■ Other topical treatments ○ Injectable treatment ■ Glutathione ■ Injectable transexamic acid ■ Platelet-rich plasma (PRP) ○ Laser treatment ■ Intense pulsed light ■ Q-switched lasers including but not limited to 1064-nm, 532-nm, 755-nm ■ Microsecond lasers ■ Nano-second lasers ■ Picosecond lasers including but not limited to 1064-nm, 532-nm, 755-nm ■ Ablative and non-ablative fractionated and non-fractionated lasers including but not limited to 10, 600-nm CO2, Erbium lasers, 1440-nm, 1550-nm, 1927-nm lasers. ○ Energy-based device treatment ■ Radiofrequency-based treatments ■ Ultrasound-based treatments ■ Temperature-based treatments
- Comparator Control
- ○ No treatment ○ Placebo ○ Gold standard
- Main Outcome
- Improvement in mucosal lip pigmentation by: ● Percentage of change of melanin index ● Percentage of change of methuen colored plate ● Percentage of change of photograph ● Patient's satisfaction score ● Change of Dermatology Life Quality Index (DLQI) score ● Pain score
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- Michelle Demetres [email protected]
- Organisational Affiliation
- Weill Cornell Medicine
- Funding Source
- To compare intervention modalities for acquired lip hyperpigmentation in terms of efficacy, safety, side effects, complications, and patient's satisfaction.None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-02-28
- Registration Date
- 2023-03-11
- Anticipated Start Date
- 2023-02-21
- Anticipated Completion Date
- 2023-05-01
- Title Cn
- 获得性唇部色素沉着的治疗：一项系统评价与Meta分析
- Title En
- Acquired Lip Hyperpigmentation Treatments: a systematic review and meta analysis
- Bilingual Status
- complete