Meta AnalysisID 7648
氨基葡萄糖治疗腰椎管狭窄症的有效性和安全性：一项系统评价与Meta分析
CRD42023473320
Is the treatment of glucosamine effective for patients with lumbar spinal stenosis in terms of pain relief ? Is glucosamine a better choice for the treatment of lumbar spinal stenosis?
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Record Fields
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- Meta Analysis Id
- 7648
- Evidence Id
- 16206
- Core Evidence Id
- 16206
- Source Meta Analysis Id
- 7643
- Herb2 Meta Analysis Id
- HBMA007643
- Crd Id
- CRD42023473320
- Title
- The efficacy and safety of Glucosamine in the treatment of lumbar spinal stenosis:a systematic review and meta-analysis
- Review Question
- Is the treatment of glucosamine effective for patients with lumbar spinal stenosis in terms of pain relief ? Is glucosamine a better choice for the treatment of lumbar spinal stenosis?
- Study Type Included
- We will include only randomised controlled trials (RCTs) published in English.
- Condition Being Studied
- Lumbar spinal stenosis (LSS) is a degenerative diease of the spine, its main clinical manifestations are lower back pain and intermittent claudication. The incidence of the disease in the world is increasing year by year, and the age of onset is gradually getting younger. At present, conservative treatment and surgical treatment are mainly used for patients with lumbar spinal stenosis, among which anti-inflammatory and analgesic drugs are mostly used in conservative drug treatment. As the fourth most commonly used dietary supplement in the world, glucosamine is believed to store cartilage and has anti-inflammatory properties, and has been widely used in the prevention and treatment of osteoarthritis in recent years. Therefore, the aim of this study was to investigate the efficacy and safety of glucosamine alone in the treatment of lumbar degenerative diseases.
- Participant
- Inclusion: people with lumbar spinal stenosis who meet the diagnostic criteria of the North American Spine Association(NASS). No restrictions for gender, age and severity of lumbar spinal stenosis. Exclusion: Patients with mental disease or other chronic diseases, or injuries of low back.
- Animal
- Human Disease Modelled
- Intervention
- Intervention:studies that investigated the effects of oral administration of the glucosamine, no matter of its dose and frequency. Exclusion: Studies in which patients were receiving any other interventions like physiotherapy, anti-inflammatory drugs and so on.
- Comparator Control
- Studies that included using one drug alone or placebos which are totally same with glucosamine in shape, smell and package.
- Main Outcome
- 1.Disability and functional status will be measured by RMDQ, NASS, EQ-5D or any other. 2. Pain intensity will be measured by VAS, NRS, McGill Pain Scale or any other. Measures of effect We will divide the research result datas that reported results at multiple time points into short-term and long-term follow-up, evaluating pain score as well as measuring body function index, and make network meta-analysis at the corresponding time points. If the NMA can be available, mean difference (MD) or standardized mean difference (SMD) and 95% confidence interval (CI) will be used; Otherwise, a narrative description of the results will be provided only.
- Outcome Measure
- Additional Outcome
- Detail improvement in function, pain and stiffness. The progression of lumbar degeneration. And the adverse effect. Measures of effect Health-related quality of life was measured using EuroQol-5 Dimensions (EQ-5D) index and EuroQol-visual analog scale (EQ-VAS).The effect sizes of all above will be expressed as Mean Differences (MDs).The adverse effect (AE) will be measured by the rate of adverse events. The effect sizes of AE will be expressed as Relative Risks (RR).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Tongtong Zhang [email protected]
- Organisational Affiliation
- Beijing University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-31
- Registration Date
- 2023-11-11
- Anticipated Start Date
- 2023-10-20
- Anticipated Completion Date
- 2024-06-30
- Title Cn
- 氨基葡萄糖治疗腰椎管狭窄症的有效性和安全性：一项系统评价与Meta分析
- Title En
- The efficacy and safety of Glucosamine in the treatment of lumbar spinal stenosis:a systematic review and meta-analysis
- Bilingual Status
- complete