Meta AnalysisID 7639
链脲佐菌素诱导的啮齿类阿尔茨海默病动物模型预测效度的系统评价与网状Meta分析
CRD42023468989
The purpose of this study was to confirm predictive validity of transgenic animal models of Alzheimer's disease (AD) in rodents, that is to compare the pharmacological interventions on behavioral performance of learning,
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Record Fields
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- Meta Analysis Id
- 7639
- Evidence Id
- 16197
- Core Evidence Id
- 16197
- Source Meta Analysis Id
- 7633
- Herb2 Meta Analysis Id
- HBMA007633
- Crd Id
- CRD42023468989
- Title
- Systematic review and network meta-analysis of predictive validity of streptozocin (STZ)-induced animal models of Alzheimer's disease in rodents
- Review Question
- The purpose of this study was to confirm predictive validity of transgenic animal models of Alzheimer's disease (AD) in rodents, that is to compare the pharmacological interventions on behavioral performance of learning, memory, and cognitive deficit in different rodent transgenic animal models of AD. Context and rationale Alzheimer's disease (AD) is the main cause of dementia and is quickly becoming one of the most expensive, lethal, and burdening diseases of this century. The most recent data indicate that, by 2050, the prevalence of dementia will triple worldwide. The earliest phase of AD (cellular phase) happens in parallel with accumulating amyloid β (Aβ), inducing the spread of tau pathology. The pathology of AD is characterized by the deposition of Aβ plaques and neurofibrillary tangles primarily in the neocortex and hippocampus. According to the amyloid hypothesis of AD, the build-up of Aβ initiates a cascade of harmful events that lead to neuronal dysfunction. More than lifestyle choices and genetic predisposition, old age is the primary risk factor for AD development, but exactly how brain ageing is linked to amyloid deposition is unclear. A large number of animal models have been generated for investigation of AD mechanisms and evaluation of potential AD therapeutics. Most of these animal models are transgenic mouse models generated by overexpression of mutated human PS1, APP, and/or tau. Streptozotocin (STZ) is a diabetogenic compound and is commonly used to induce diabetes in animals when administered in the periphery due to its activity to damage the pancreatic β cells and to induce insulin resistance. Brain insulin resistance, decreased brain glucose metabolism, cholinergic deficits, accumulation of tau and Aβ, oxidative stress, gliosis, and learning and memory deficits have been reported in the STZ-induced animal models in rodents. Accordingly, this study is to confirm STZ-induced animal models of AD in rodents.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group, and experimental groups. Exclusion criteria: Absence of experimental or control groups.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Rodent animal models of Alzheimer's disease (AD), induced by streptozotocin (STZ); regardless of species, strains, age, and sex. Exclusion criteria: Experimental group included by non-STZ administration.
- Human Disease Modelled
- Alzheimer's disease (AD).
- Intervention
- Inclusion criteria: Pharmacological intervention, such as cholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine, huperzine A), and N-methyl-D-aspartic acid (NMDA) receptor antagonist (memantine), etc.; regardless of the route, time, duration, or dose. Exclusion criteria: All other conditions and/or absence of experimental groups induced by the list above.
- Comparator Control
- Inclusion criteria: A control/vehicle or any other pharmacological intervention. Exclusion criteria: Studies that do not include a second group with no treatment, vehicle, or intervention with another drug.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Behavioral performance of learning, memory, and cognitive deficit, such as in Morris water maze (s, continuous), novel object recognition test (s, continuous), radial maze (s, continuous), Barnes maze (s, continuous), etc. Exclusion criteria: No investigation of learning, memory, and cognitive deficits behavior in relation to models.
- Additional Outcome
- Study Method
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Hongxing ZHANG [email protected]
- Organisational Affiliation
- Jinan Hospital of Traditional Chinese Medicine
- Funding Source
- This work was supported by High Level Talent Cultivation Project of Traditional Chinese Medicine of Shandong Province (2023 No. 143 Letter, Health Commission of Shandong Province); Project of National Famous and Old Traditional Chinese Medicine Expert ZHANG Hong-xing Inheritance Studio (2022 No. 75 Human Education Letter, National Administration of Traditional Chinese Medicine); Natural Science Foundation of Shandong Province (ZR2019MH063); Project of Traditional Chinese Medicine Science and Technology of Shandong Province (2021Q061, 2021Q099); and Project of Traditional Chinese Medicine Science and Technology Development of Shandong Province (2019-0222, 2019-0218, 2019-0215, 2017-113, 2017-115, 2015-131).
- Other Selection Criteria
- None.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-03
- Registration Date
- 2023-12-20
- Anticipated Start Date
- 2023-08-01
- Anticipated Completion Date
- 2024-09-30
- Title Cn
- 链脲佐菌素诱导的啮齿类阿尔茨海默病动物模型预测效度的系统评价与网状Meta分析
- Title En
- Systematic review and network meta-analysis of predictive validity of streptozocin (STZ)-induced animal models of Alzheimer's disease in rodents
- Bilingual Status
- complete