Meta AnalysisID 7628
来曲唑联合氯米芬对比单用来曲唑用于多囊卵巢综合征女性诱导排卵：系统评价与Meta分析
CRD42023465036
Is letrozole and clomiphene more effective than letrozole alone for ovulation induction in women with polycystic ovary syndrome?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7628
- Evidence Id
- 16186
- Core Evidence Id
- 16186
- Source Meta Analysis Id
- 7622
- Herb2 Meta Analysis Id
- HBMA007622
- Crd Id
- CRD42023465036
- Title
- Letrozole and clomiphene versus letrozole alone for ovulation induction in women with polycystic ovary syndrome: a systematic review and meta-analysis
- Review Question
- Is letrozole and clomiphene more effective than letrozole alone for ovulation induction in women with polycystic ovary syndrome?
- Study Type Included
- Randomized controlled trials and observational studies
- Condition Being Studied
- Nearly 70% of patients with polycystic ovary syndrome (PCOS) have anovulatory infertility. One therapeutic option is letrozole, however, its comparative efficacy and safety when compared with the association of letrozole and clomiphene citrate is unclear. Therefore, we aimed to compare letrozole and the combined use of letrozole and clomiphene citrate for ovulation induction in PCOS.
- Participant
- Women with PCOS and anovulatory infertility.
- Animal
- Human Disease Modelled
- Intervention
- Letrozole and clomiphene
- Comparator Control
- Letrozole alone
- Main Outcome
- Ovulation and women with mature follicles (>15mm) Measures of effect Odds ratio, mean difference
- Outcome Measure
- Additional Outcome
- Ovulation, pregnancy, singleton pregnancy, twin pregnancy, pregnancy loss, fecundity, live birth, Cycle day of LH surge, number of mature follicles (>15mm), largest follicle, endometrial lining thickness, progesterone level, headache, hot flushes, abdominal bloating, abdominal pain, nausea, vomiting, mood changes, fatigue, back pain, dizziness, breast discomfort, diarrhea, insomnia, night sweats, congenital birth defects Measures of effect Odds ratio, mean difference
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Karine Eskandar [email protected]
- Organisational Affiliation
- Pontificia Universidade Catolica do Parana
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-19
- Registration Date
- 2023-09-30
- Anticipated Start Date
- 2023-09-01
- Anticipated Completion Date
- 2023-11-20
- Title Cn
- 来曲唑联合氯米芬对比单用来曲唑用于多囊卵巢综合征女性诱导排卵：系统评价与Meta分析
- Title En
- Letrozole and clomiphene versus letrozole alone for ovulation induction in women with polycystic ovary syndrome: a systematic review and meta-analysis
- Bilingual Status
- complete