Meta AnalysisID 7627
序贯来曲唑与促性腺激素治疗多囊卵巢综合征不孕女性诱导排卵的有效性：随机对照试验的系统评价与Meta分析
CRD42023463333
What is the effectiveness of sequential letrozole and gonadotropins therapy versus other interventions or placebo for ovulation induction in infertile women with polycystic ovarian syndrome?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7627
- Evidence Id
- 16185
- Core Evidence Id
- 16185
- Source Meta Analysis Id
- 7621
- Herb2 Meta Analysis Id
- HBMA007621
- Crd Id
- CRD42023463333
- Title
- Effectiveness of sequential Letrozole and Gonadotropins therapy for ovulation induction in infertile women with PCOS: A systematic review and meta-analysis of randomized controlled trials (RCTs)
- Review Question
- What is the effectiveness of sequential letrozole and gonadotropins therapy versus other interventions or placebo for ovulation induction in infertile women with polycystic ovarian syndrome?
- Study Type Included
- Randomized controlled trials (RCTs)
- Condition Being Studied
- Polycystic ovarian syndrome (PCOS) is a highly prevalent, genetically complex, and heterogeneous endocrine disorder in reproductive-aged women, affecting 5% to 20% worldwide. It is a common cause of hyperandrogenism, anovulatory infertility, menstrual dysfunction, and hirsutism. It appears to be associated with an increased risk of metabolic abnormalities such as insulin resistance, hyperinsulinism, type 2 diabetes mellitus, dyslipidaemia, cardiovascular diseases, and endometrial carcinoma. PCOS accounts for more than 80% of women with anovulatory infertility. Ovulation induction therapy is a classical treatment for women with anovulatory PCOS who wish to conceive.
- Participant
- It will include RCTs reporting infertile women with PCOS of any age, race or ethnicity. Women with PCOS who are diagnosed by Rotterdam Criteria, with normal TSH, and prolactin levels, and with normozoospermic male partners, having unprotected timed-intercourse and duration of their infertility is longer than 1 year. All other studies reporting women with infertility caused by disorders other than PCOS, with a history of ovarian surgery or complications with endometriosis or pelvic adhesion, patients complicated with liver, kidney, or thyroid dysfunction, women with CAH and gynaecological surgeries, women with autoimmune diseases, tubal obstruction, and who are allergic to relevant drugs will be excluded from the review.
- Animal
- Human Disease Modelled
- Intervention
- We will include studies reporting sequential letrozole and gonadotropins for ovulation induction. Letrozole, an aromatase inhibitor, in combination with gonadotropins, has shown promising results in women with PCOS, including CC-resistant PCOS patients. Gonadotropins, when given in combination with ovulation-inducing drugs, reduce the risk of complications while maintaining higher pregnancy rates. In clinical trials, letrozole plus gonadotropins sequential therapy has resulted in higher pregnancy rates and live births than any other intervention, including CC. Moreover, It proved to be efficient in the case of CC-resistant PCOS patients due to its indirect effect on estrogen.
- Comparator Control
- The placebo or other standard regimens for ovulation induction in infertile women with PCOS.
- Main Outcome
- The primary outcome of this review will be ovulation induction. Secondary outcomes may include follicular growth, increased rate of pregnancy and ultimately live births in infertile women. Measures of effect Relative Risk of main outcome will be measured.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Muhammad Nabeel Saddique [email protected]
- Organisational Affiliation
- King Edward Medical University, Mayo Hospital, Lahore 54000 www.kemu.edu.pk
- Funding Source
- This review is not funded by any individual, organization, group, company or any other legal entity.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- No, there is no systematic review on the same topic by same authors on any database.
- Published Protocol
- Review Type
- Language
- English
- Country
- Pakistan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-13
- Registration Date
- 2023-09-24
- Anticipated Start Date
- 2023-07-01
- Anticipated Completion Date
- 2023-11-30
- Title Cn
- 序贯来曲唑与促性腺激素治疗多囊卵巢综合征不孕女性诱导排卵的有效性：随机对照试验的系统评价与Meta分析
- Title En
- Effectiveness of sequential Letrozole and Gonadotropins therapy for ovulation induction in infertile women with PCOS: A systematic review and meta-analysis of randomized controlled trials (RCTs)
- Bilingual Status
- complete