Meta AnalysisID 7622
丁香酚对口腔癌细胞系的体外抗癌作用：系统评价
CRD42023437406
Eugenol has been reported to exhibit anticancer activity on several human cancer cells and be able to induce cancer cell death. Several studies also have reported the anticancer activity of eugenol against oral squamous
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7622
- Evidence Id
- 16180
- Core Evidence Id
- 16180
- Source Meta Analysis Id
- 7616
- Herb2 Meta Analysis Id
- HBMA007616
- Crd Id
- CRD42023437406
- Title
- In Vitro Anticancer Effect of Eugenol on Oral Cancer Cell Lines: A Systematic Review
- Review Question
- Eugenol has been reported to exhibit anticancer activity on several human cancer cells and be able to induce cancer cell death. Several studies also have reported the anticancer activity of eugenol against oral squamous cell carcinoma cell through different pathways. Therefore, the search aimed to answer the following focused question: "How are the anticancer effects of eugenol against oral cancer cell lines on in vitro studies?"
- Study Type Included
- In vitro (ex vivo) studies
- Condition Being Studied
- Oral cancer has become a global health problem due to its high incidence and mortality rates. The most common type of oral cancer is oral squamous cell carcinoma (OSCC). Eugenol is widely used due to its many pharmacological activities. Eugenol is an aromatic compound of the phenol group and has been used as an anticancer agent. Several studies have reported the anticancer activity of eugenol against OSCC through different pathways. Eugenol has been reported to induce cancer cell death, suppress the cancer malignancy process, and inhibit the proliferation and biological activity of cancer cells. However, there is no current review discussing the extent of eugenol anticancer research against oral cancer cell lines on in vitro study. Therefore, the purpose of this systematic review is to discuss the anticancer effects of eugenol against oral cancer cell lines on in vitro studies.
- Participant
- Oral cancer cells
- Animal
- Human Disease Modelled
- Intervention
- Eugenol exposure, in vitro (ex vivo) study
- Comparator Control
- Vehicle control or non-exposed control group
- Main Outcome
- Anticancer effects of eugenol against oral cancer cell lines on in vitro studies Measures of effect Not applicable
- Outcome Measure
- Additional Outcome
- Mechanism of anticancer activity of eugenol against oral cancer cell lines on in vitro studies Measures of effect Not applicable
- Study Method
- Pre-clinical, Systematic review
- Keyword
- Carcinoma, Squamous Cell; Cell Death; Cell Line; Eugenol; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Squamous Cell Carcinoma of Head and Neck
- Contact
- Shafa Nafisa Wulan [email protected]
- Organisational Affiliation
- Universitas Padjadjaran
- Funding Source
- Self-funded
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Indonesia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-21
- Registration Date
- 2023-07-02
- Anticipated Start Date
- 2023-02-07
- Anticipated Completion Date
- 2023-07-20
- Title Cn
- 丁香酚对口腔癌细胞系的体外抗癌作用：系统评价
- Title En
- In Vitro Anticancer Effect of Eugenol on Oral Cancer Cell Lines: A Systematic Review
- Bilingual Status
- complete