Meta AnalysisID 7584
评估维生素D作为替代FDA批准治疗及其他疗法管理绝经后女性外阴阴道萎缩与性不活跃的有效性：一项系统评价与Meta分析
CRD42023474020
Could we consider vitamin D as an alternative therapy to other available therapies in the treatment and management of vaginal atrophy and sexual dysfunction in menopause and postmenopause?
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Record Fields
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- Meta Analysis Id
- 7584
- Evidence Id
- 16142
- Core Evidence Id
- 16142
- Source Meta Analysis Id
- 7577
- Herb2 Meta Analysis Id
- HBMA007577
- Crd Id
- CRD42023474020
- Title
- A systematic review and meta-analysis to assess the effectiveness of vitamin D as an alternative to FDA-approved treatment and other therapies for managing vulvovaginal atrophy and sexual inactivity in postmenopausal women
- Review Question
- Could we consider vitamin D as an alternative therapy to other available therapies in the treatment and management of vaginal atrophy and sexual dysfunction in menopause and postmenopause?
- Study Type Included
- We will include randomized controlled trials (all RCTs in any language) that deal with the effect of different routes of administration of vitamin D (orally or topically, such as vaginal suppositories or vaginal cream) in managing vulvovaginal atrophy, vaginal PH, dyspareunia, sexual inactivity, and dysfunction, and on improving the vaginal maturation index and female sexual function index in menopausal and postmenopausal women.
- Condition Being Studied
- Vaginal atrophy, vulvovaginal atrophy, vaginal dryness, dyspareunia, and sexual inactivity and dysfunction as major symptoms of menopause and postmenopause
- Participant
- 1. 45 years old and above healthy menopausal /postmenopausal women 2. Breast Cancer menopausal /postmenopausal females who previously had taking radiotherapy or chemotherapy or hormonal /Endocrine such as; tamoxifen or Aromatase inhibitors (AIs) or any other hormonal therapy which decreases estrogen level and causes a genitourinary syndrome of menopause (GSM) mainly “Vaginal atrophy “, vaginal dryness as a major side effect. 3. Menopausal Women who have a history of cancer, or who are at high risk of cancer, or have current mild/moderate stages of breast cancer 4. Menopausal/postmenopausal women who have cardiovascular disease (CVD) or at moderate or high risk of CVD or who have venous thromboembolism (VTE) or a history of VTE 6. Menopausal/ postmenopausal women who have urinary incontinence ( stress incontinence ) 7. Menopausal/postmenopausal women who have (GSM) particularly, Vulvovaginal atrophy and sexual inactivity and dysfunction 8. Menopausal/postmenopausal women who are sexually active and/or have low female sexual function index scale ( FSFI ) </=26.55, and who have a low vaginal health index Exclusion criteria: 1. Women younger than 40 years 2. Women have a recurrent vaginal infection or urinary tract infections (UTI) 4. Observational studies, reviews, Post hoc studies, Duplication publication
- Animal
- Human Disease Modelled
- Intervention
- Vitamin D (cholecalciferol D3 or calcitriol, alpha-calcidiol, or ergocalciferol D2) in different dosage forms and routes of administration (oral supplements, injections, or topical forms such as vaginal suppositories, creams, or gels) alone or in combination with other therapies (Ca2+, Raloxifene, isoflavone, and others)
- Comparator Control
- Different comparators: Placebo or control group or HRT ( Hormonal replacement therapy such as Estrogen and/or progestogen ), or other drugs such as Raloxifene or Ca 2+ or combined estrogen
- Main Outcome
- Evaluate the improvement in VMI ( vaginal maturation index)
- Outcome Measure
- Additional Outcome
- FSFI ( female sexual function index)
- Study Method
- Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Eman Youssef [email protected]
- Organisational Affiliation
- Medical Group of Research of Egypt, Negida Academy, Arlington, MA
- Funding Source
- no funding was provided to this systematic review and meta-analysis
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Egypt
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-18
- Registration Date
- 2023-10-29
- Anticipated Start Date
- 2023-10-18
- Anticipated Completion Date
- 2024-01-15
- Title Cn
- 评估维生素D作为替代FDA批准治疗及其他疗法管理绝经后女性外阴阴道萎缩与性不活跃的有效性：一项系统评价与Meta分析
- Title En
- A systematic review and meta-analysis to assess the effectiveness of vitamin D as an alternative to FDA-approved treatment and other therapies for managing vulvovaginal atrophy and sexual inactivity in postmenopausal women
- Bilingual Status
- complete