Meta AnalysisID 7514
抗氧化治疗在COVID-19治疗和预后中的作用：随机对照试验的系统评价与Meta分析
CRD42023430805
Does antioxidant therapy vs placebo reduce the severity of COVID-19?
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Record Fields
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- Meta Analysis Id
- 7514
- Evidence Id
- 16072
- Core Evidence Id
- 16072
- Source Meta Analysis Id
- 7507
- Herb2 Meta Analysis Id
- HBMA007507
- Crd Id
- CRD42023430805
- Title
- Role of antioxidant therapy in the treatment and prognosis of COVID-19: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- Does antioxidant therapy vs placebo reduce the severity of COVID-19?
- Study Type Included
- Inclusion: Randomized controlled trials Exclusion: animal models, quasi-experimental, In vitro studies, observational studies, no control group, reviews, opinion papers, case-study, conference abstracts
- Condition Being Studied
- COVID-19 (viral respiratory illness) and its clinical consequences (i.e. time to recovery, overall mortality, ICU and hospital stays) will be studied.
- Participant
- Inclusion: humans of all ages, genders or ethnicities with acute COVID-19 Exclusion: animal models, in vitro models, individuals without acute COVID-19
- Animal
- Human Disease Modelled
- Intervention
- This review will include studies that have investigated the following methods of delivering antioxidant micronutrients (including selenium, zinc, copper, vitamin A, retinol, β-carotene, lycopene, vitamin C, vitamin E): enteral, parenteral/intravenous or both.
- Comparator Control
- Control group will consist of placebo (COVID-19 patients who were not exposed to antioxidant micronutrients).
- Main Outcome
- Severity of COVID-19 will be assessed with the following outcomes: Time to recovery (days) Overall mortality ICU and hospital stays (days) Artificial ventilation Change in inflammatory biomarkers (such as CRP, IL-6, D-Dimer) Severity and duration of symptoms Long COVID
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Prognostic, Systematic review
- Keyword
- Antioxidants; COVID-19; Dietary Supplements; Humans; Prognosis; Randomized Controlled Trials as Topic
- Contact
- Radha Sharma [email protected]
- Organisational Affiliation
- Upstream Lab, MAP Centre for Urban Health Solutions, Unity Health Toronto https://upstreamlab.org/
- Funding Source
- CanTreatCOVID Trial Funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Completed not published
- First Submission Date
- 2023-06-05
- Registration Date
- 2023-06-05
- Anticipated Start Date
- 2023-05-31
- Anticipated Completion Date
- 2023-08-31
- Title Cn
- 抗氧化治疗在COVID-19治疗和预后中的作用：随机对照试验的系统评价与Meta分析
- Title En
- Role of antioxidant therapy in the treatment and prognosis of COVID-19: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete