Meta AnalysisID 7481
二乙酰吗啡用于阿片受体激动剂治疗的有效性：基于患者报告结局的系统评价
CRD42023492183
Is opioid agonist treatment with intravenous diacetylmorphine alone or in combination with another opioid agonist treatment medication more effective in opioid-dependent individuals in improving mental or physical health
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7481
- Evidence Id
- 16039
- Core Evidence Id
- 16039
- Source Meta Analysis Id
- 7474
- Herb2 Meta Analysis Id
- HBMA007474
- Crd Id
- CRD42023492183
- Title
- Effectiveness of diacetylmorphine for opioid agonist treatment: A systematic review of patient-reported outcomes
- Review Question
- Is opioid agonist treatment with intravenous diacetylmorphine alone or in combination with another opioid agonist treatment medication more effective in opioid-dependent individuals in improving mental or physical health, reducing drug use (including alcohol), improving quality of life, or social functioning compared to opioid agonist treatment with racemic methadone, levomethadone, buprenorphine, buprenorphine/naloxone, codeine, slow-release morphine, or dihydrocodeine?
- Study Type Included
- We will include randomized controlled trials (RCTs), non-randomized controlled trials (NRS), or observational studies (prospective or retrospective cohort studies or case-control studies). We will exclude qualitative studies, cross-sectional studies, cost-effectiveness studies, mathematical modeling studies, ecological studies, case series, and principally studies with no intervention and control group.
- Condition Being Studied
- Opioid use disorder/opioid dependence. Opioid agonist treatment for improving patient-reported outcomes.
- Participant
- Inclusion: Adults with opioid use disorder/opioid dependence from illegal opioids (as diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (DSM) or the International Classification of Diseases (ICD)). Exclusion: Neonatals, children and adolescents (under 18 years of age), pregnant people, only veterans, indigenous people, people with illegal status or people in prison as study population, people who are addicted to (prescribed) opioids as pain-relieving medicine.
- Animal
- Human Disease Modelled
- Intervention
- Opioid agonist treatment (OAT) with intravenous diacetylmorphine alone or in combination with another OAT medication such as racemic methadone, levomethadone, buprenorphine, buprenorphine/naloxone, codeine, slow-release oral morphine or dihydrocodeine.
- Comparator Control
- Opioid agonist treatment (OAT) with racemic methadone, levomethadone, buprenorphine, buprenorphine/naloxone, codeine, slow-release oral morphine or dihydrocodeine.
- Main Outcome
- Changes in the patient-reported outcomes (PRO) mental health, physical health, drug use incl. alcohol, quality of life, treatment satisfaction, and social functioning from baseline to at least six months follow-up.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Kirsten Lehmann [email protected]
- Organisational Affiliation
- University Medical Center Hamburg-Eppendorf, Centre for Interdisciplinary Addiction Research https://www.zis-hamburg.de
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Germany
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-10
- Registration Date
- 2023-12-21
- Anticipated Start Date
- 2023-12-17
- Anticipated Completion Date
- 2024-09-01
- Title Cn
- 二乙酰吗啡用于阿片受体激动剂治疗的有效性：基于患者报告结局的系统评价
- Title En
- Effectiveness of diacetylmorphine for opioid agonist treatment: A systematic review of patient-reported outcomes
- Bilingual Status
- complete