Meta AnalysisID 7475
牙髓治疗中螯合剂的应用进展：一项系统评价
CRD42023425927
The review question is: “During endodontic treatment and pulp regeneration therapies, which chelating agents provide optimal characteristics in terms of efficacy, low erosion and cytotoxicity, no interaction with other i
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Record Fields
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- Meta Analysis Id
- 7475
- Evidence Id
- 16033
- Core Evidence Id
- 16033
- Source Meta Analysis Id
- 7467
- Herb2 Meta Analysis Id
- HBMA007467
- Crd Id
- CRD42023425927
- Title
- Update on chelating agents in endodontic treatment: a systematic review
- Review Question
- The review question is: “During endodontic treatment and pulp regeneration therapies, which chelating agents provide optimal characteristics in terms of efficacy, low erosion and cytotoxicity, no interaction with other irrigants, adhesion of the filling material, high antimicrobial effect and presence of growth factors? The PICO (Patients, Intervention, Comparison, Outcomes) measured are: P: human teeth, animal models in case of cytotoxicity studies I: irrigation with at least one of the chelating agents: 17% EDTA, 9% - 18% HEBP, 10%-20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid. C: any final irrigant. O: efficacy, erosion, interaction with other irrigating substances, antimicrobial effect, cytotoxicity, adhesion of filling materials, release of growth factors and stem cell behavior with the use of different chelating agents.
- Study Type Included
- In vitro studies and randomized clinical trials that evaluated at least one of the chelating agents (17% EDTA, 9% and 18% HEBP, 10% and 20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid).
- Condition Being Studied
- Comparison of properties between the main chelating agents used in endodontics
- Participant
- The inclusion criteria include: - in vitro studies with extracted human teeth without caries, mature apex and absence of resorption or endodontic filling. With the exception of studies on cytotoxicity where animal studies will be permitted. - The studies must have at least one of the following chelating agents with their respective concentrations: EDTA 17%, 9% and 18% HEBP, 10% and 20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid. The number of samples accepted per subgroup within a study must be equal to or greater than five. Exclusion criteria: - Studies published prior to 2010 and with a low impact factor (Q3 or Q4).
- Animal
- Human Disease Modelled
- Intervention
- Irrigation of the samples with at least one of the following chelating agents and respective concentrations: EDTA 17%, 9% and 18% HEBP, 10% and 20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid.
- Comparator Control
- Studies must contain at least one of the following chelators with their respective concentrations: EDTA 17%, 9% and 18% HEBP, 10% and 20% citric acid, 2%-2.25% peracetic acid and 7% maleic acid and may be compared with each other or with another chelating agent or with control groups (distilled water or saline solution).
- Main Outcome
- - Chelators effectiveness/erosion: chelation can lead to changes in dentin microstructure, resulting in reduced dentin strength. To evaluate the effectiveness and erosion of different chelating agents, have been used: SEM, AAS, CLSM, OM, and inductively coupled plasma-atomic emission spectrometry. - Irrigant interaction: an irrigant may not be completely flushed out of the root canal before using the next irrigant, and chemical reactions may occur. These reactions can be evaluated by Electrospray ionization quadrupole time-of-flight mass spectrometry, and Iodometric titration. - Antimicrobial effect: bacteria are often found within the root canals with persistent apical periodontitis.To antimicrobial activity can be evaluated by: Confocal Laser Scanning Microscope analysis, scanning electron microscopy, colony-forming units. - Cytotoxicity: Chelating agents must be compatible with the periapical tissues. To assess cytotoxicity can be used: methylthiazole tetrazolium, clonogenic, enzyme-linked immunosorbent assay, transmission electron microscopy, Flow cytometry analysis, scanning electron microscopy. - Sealer adhesion to dentine: smear layer hinders the adhesion of sealers to dentin. To assess adhesion of sealers can be used: push-out test, Atomic force microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy. - Intervention in regenerative endodontic procedures: The release of growth factors increases the effectiveness of regenerative procedures. To evaluate: Flow cytometric analysis, Alizarin red S staining, SEM, CLSM.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Systematic review
- Keyword
- Animals; Chelating Agents; Citric Acid; Dental Pulp; Humans; Peracetic Acid; Regeneration; Stem Cells; maleic acid
- Contact
- Montse Mercade [email protected]
- Organisational Affiliation
- Universitat de Barcelona
- Funding Source
- No funding received
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Spain
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-22
- Registration Date
- 2023-06-03
- Anticipated Start Date
- 2023-01-02
- Anticipated Completion Date
- 2023-08-01
- Title Cn
- 牙髓治疗中螯合剂的应用进展：一项系统评价
- Title En
- Update on chelating agents in endodontic treatment: a systematic review
- Bilingual Status
- complete