Meta AnalysisID 7454
营养补充剂改善多囊卵巢综合征糖脂代谢和内分泌功能的比较：系统评价和网状Meta分析
CRD42023441257
Comparison of effects of multiple nutritional supplements on glucose and lipid metabolism and endocrine function in patients with polycystic ovary syndrome: A Systematic review and network meta-analysis of randomized con
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Record Fields
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- Meta Analysis Id
- 7454
- Evidence Id
- 16012
- Core Evidence Id
- 16012
- Source Meta Analysis Id
- 7460
- Herb2 Meta Analysis Id
- HBMA007460
- Crd Id
- CRD42023441257
- Title
- Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: A systematic review and network meta-analysis
- Review Question
- Comparison of effects of multiple nutritional supplements on glucose and lipid metabolism and endocrine function in patients with polycystic ovary syndrome: A Systematic review and network meta-analysis of randomized controlled trials.
- Study Type Included
- RCT
- Condition Being Studied
- Polycystic ovary syndrome (PCOS) is a common gynecological Endocrine disease, affecting about 8% -15% of women of childbearing age. PCOS is a heterogeneous disease characterized by a combination of signs and symptoms of androgen excess and ovarian dysfunction. The pathogenesis of PCOS may be related to factors such as hyperandrogenism, insulin resistance, obesity, metabolic abnormalities, and inflammation. Patients with PCOS have a higher risk of type 2/gestational diabetes, Atherosclerosis Dyslipidemia, systemic inflammation, nonalcoholic fatty liver disease, hypertension and coagulation disorders. Due to the complexity of the pathogenesis of PCOS, certain nutritional supplements are currently receiving widespread attention due to their potential benefits in improving endocrine and metabolic disorders. Research has shown that nutritional supplements can offset the risk of disease progression and cardiovascular events by offsetting the impact of oxidative stress on PCOS. Vitamin, mineral, probiotic, and other dietary supplements have significant benefits in reducing symptoms related to PCOS. Supplementing natural molecules such as inositol, vitamin E, vitamin D, and omega-3 may help overcome the pathological characteristics of PCOS, including immature oocytes, insulin resistance, hyperandrogenism, oxidative stress, and inflammation. However, there are still shortcomings in the direct comparison of different nutritional supplements in the treatment of PCOS.
- Participant
- The inclusion criteria is female patients diagnosed with polycystic ovary syndrome according to Rotterdam or National Institutes of Health standards, aged 18-49 years old.
- Animal
- Human Disease Modelled
- Intervention
- Use one of nutritional supplements, including selenium, chromium, carnitine, inositol, Coenzyme Q10, Omega-3, probiotics, vitamin D and vitamin E, for a duration of 8 weeks at least.
- Comparator Control
- Use placebo or one of nutritional supplements, including selenium, chromium, carnitine, inositol, Coenzyme Q10, Omega-3, probiotics, vitamin D and vitamin E, for a duration of 8 weeks at least .
- Main Outcome
- Weight、BMI、Fasting blood glucose、Fasting insulin、HOMA-IR、QUICKI、TG、TC、LDL-C、HDL-C、Total testosterone、SHBG、CRP
- Outcome Measure
- Additional Outcome
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Female; Glucose; Glycolipids; Humans; Lipid Metabolism; Lipids; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic
- Contact
- Xinyin Hu [email protected]
- Organisational Affiliation
- Beijing University of Chinese Medicine
- Funding Source
- No funding sources/sponsors
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-01
- Registration Date
- 2023-07-11
- Anticipated Start Date
- 2023-03-01
- Anticipated Completion Date
- 2023-07-30
- Title Cn
- 营养补充剂改善多囊卵巢综合征糖脂代谢和内分泌功能的比较：系统评价和网状Meta分析
- Title En
- Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: A systematic review and network meta-analysis
- Bilingual Status
- complete