Meta AnalysisID 7451
补充甲基营养素对轻度认知障碍老年人认知功能的影响：系统评价与Meta分析
CRD42023406077
Whether methyl nutritions supplementation has a positive effect on cognitive function in older adults with mild cognitive impairment.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7451
- Evidence Id
- 16009
- Core Evidence Id
- 16009
- Source Meta Analysis Id
- 7444
- Herb2 Meta Analysis Id
- HBMA007444
- Crd Id
- CRD42023406077
- Title
- Effect of supplementation with methyl nutritions on cognition of elderly with mild cognitive impairment: a systematic review and meta-analysis
- Review Question
- Whether methyl nutritions supplementation has a positive effect on cognitive function in older adults with mild cognitive impairment.
- Study Type Included
- The type of studies included were randomized controlled studies.
- Condition Being Studied
- Mild cognitive impairment (MCI) is a transition period between normal aging and diagnosis of clinically probable early Alzheimer’s disease (AD). The average annual conversion rate of MCI to dementia is about 10%, which is much higher than the annual incidence in the general population (1-2%). There is still a lack of drug therapy methods for the MCI population, some methyl nutritions have therapeutic effects on cognitive function in MCI populations, but some methyl nutritions are not.Therefore, this systematic review and meta-analysis aimed to analyze the effect of methyl nutrients on cognitive function in older adults with MCI.
- Participant
- The studies that we included were randomized controlled studies, and patients meeting the diagnostic criteria for MCI and aged older than 60 years were included
- Animal
- Human Disease Modelled
- Intervention
- Combined or separate supplementation of methyl nutrients (vitamin B12, methionine, folic acid, betaine, choline) was used for participants who meeting the inclusion criteria.
- Comparator Control
- The control group was a placebo-controlled intervention or no intervention.
- Main Outcome
- Changes in cognitive function of subjects Measures of effect In the case of homogeneity between outcome measures, data will be synthesized as correlation analysis, standardized mean differences.
- Outcome Measure
- Additional Outcome
- Memory, Space function, execution ability, and processing speed Measures of effect In the case of homogeneity between outcome measures, data will be synthesized as correlation analysis, standardized mean differences.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Aged; Cognition; Cognitive Dysfunction; Dietary Supplements; Humans
- Contact
- Yan Zhao [email protected]
- Organisational Affiliation
- Hebei Medical University https://www.hebmu.edu.cn
- Funding Source
- This work was supported by the National Natural Science Foundation of China Grant number(s) State the funder, grant or award number and the date of award grant no. 82171582.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2023-03-09
- Registration Date
- 2023-03-20
- Anticipated Start Date
- 2022-10-15
- Anticipated Completion Date
- 2023-10-31
- Title Cn
- 补充甲基营养素对轻度认知障碍老年人认知功能的影响：系统评价与Meta分析
- Title En
- Effect of supplementation with methyl nutritions on cognition of elderly with mild cognitive impairment: a systematic review and meta-analysis
- Bilingual Status
- complete