Meta AnalysisID 7450
胆碱补充与阿尔茨海默病及阿尔茨海默病相关痴呆风险的关联：系统评价与Meta分析
CRD42023395004
Are low levels of choline supplementation associated with higher risk of Alzheimer's disease and related dementias (AD/ADRD) among adult 65+? PICOT format: Population: Adults (65+) who have Alzheimer's disease and relate
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7450
- Evidence Id
- 16008
- Core Evidence Id
- 16008
- Source Meta Analysis Id
- 7443
- Herb2 Meta Analysis Id
- HBMA007443
- Crd Id
- CRD42023395004
- Title
- Association between Choline Supplementation and Alzheimer Disease(AD) and ADRD risk: A Systematic Review and Meta-Analysis
- Review Question
- Are low levels of choline supplementation associated with higher risk of Alzheimer's disease and related dementias (AD/ADRD) among adult 65+? PICOT format: Population: Adults (65+) who have Alzheimer's disease and related dementias (AD/ADRD) Intervention: Choline supplementation Comparator: There are no comparators in this review Outcome: Response to treatment for AD/ADRD (Risk ratio, hazard ratio, odd ratio, mean difference) Timing: None
- Study Type Included
- Inclusion criteria (1) original research studies(observational (cross-sectional, case-control, longitudinal) or interventional designs with a control group); (2) human studies performed in older adults , 65+; (3) studies that described the consumption of dietary choline or choline supplement, blood measurement of choline or dietary or supplementary choline; (4) studies that gave information about methods used for assessing AD, dementia, or other cognition-related health outcomes such as cognitive impairment and cognitive decline; (6) reported risk estimates (relative risk or hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for dementia or AD or provided sufficient information to calculate effect size; and (7) reported dementia or AD incidence at follow-up if longitudinal. (8) English Language Exclusion creiteria Exclusion criteria: 1) non-human subjects or in-vitro studies, 2) non-English studies, 3) case report, case series, reviews, systematic reviews, or metaanalyses, 4) abstract-only papers as preceding papers, conference, editorial, and author response thesesand books
- Condition Being Studied
- Alzheimer's disease and related dementias (AD/ADRD)
- Participant
- Adults age 65+ years
- Animal
- Human Disease Modelled
- Intervention
- Choline supplementation
- Comparator Control
- Main Outcome
- Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) outcomes, defined as changes in disease risk after treatment. Treatment outcomes can be change in choline status (OR, RR, mean, %, prevalence) Measures of effect Relative risks, Hazard ratios, odds ratios, risk difference
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Epidemiologic, Meta-analysis, Prognostic, Systematic review
- Keyword
- Alzheimer Disease; Dementia; Dietary Supplements; Humans; Odds Ratio; Proportional Hazards Models
- Contact
- Sixtus Aguree [email protected]
- Organisational Affiliation
- Indiana University https://publichealth.indiana.edu
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-10
- Registration Date
- 2023-03-21
- Anticipated Start Date
- 2023-02-15
- Anticipated Completion Date
- 2023-07-19
- Title Cn
- 胆碱补充与阿尔茨海默病及阿尔茨海默病相关痴呆风险的关联：系统评价与Meta分析
- Title En
- Association between Choline Supplementation and Alzheimer Disease(AD) and ADRD risk: A Systematic Review and Meta-Analysis
- Bilingual Status
- complete