Meta AnalysisID 7448
纳米氧化镁在骨再生中的成骨潜能——一项系统评价
CRD42023450619
Does magnesium oxide nanoparticles have osteogenic potential to promote bone regeneration?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7448
- Evidence Id
- 16006
- Core Evidence Id
- 16006
- Source Meta Analysis Id
- 7441
- Herb2 Meta Analysis Id
- HBMA007441
- Crd Id
- CRD42023450619
- Title
- Osteogenic potential of Magnesium oxide nanoparticles in bone regeneration - A systematic review
- Review Question
- Does magnesium oxide nanoparticles have osteogenic potential to promote bone regeneration?
- Study Type Included
- RCT, Invivo, Invitro
- Condition Being Studied
- Periodontal diseases are chronic inflammatory diseases caused by periodontal pathogenic bacteria which is characterised by inflammation and destruction of periodontal tissues as well as underlying alveolar bone. Guided bone regeneration (GBR) is one of the most effective approaches used in alveolar bone augmentation. GBRMs can prevent fibrous connective tissue infiltration, and provide a more suitable local environment for bone regeneration, thus promoting bone healing. Two main types of GBRMs, non-resorbable and resorbable membranes, have emerged to date. Conventional biomembranes and cellulose films used in guided tissue regeneration (GTR) can prevent the downgrowth of epithelial cells, fibroblasts, and connective tissue in the area of tooth root but have limitations related to osteogenic and antimicrobial properties.Magnesium (Mg) and its alloys have gained increasing attention as a new class of biodegradable metallic material, due to their good biocompatibility and mechanical properties . However, only few studies have focused on the use of Mg alloys as barrier membranes for GBR. Magnesium oxide nanoparticles (MgONPs) possess biodegradability and lower toxicity. Furthermore, the benefits of MgONPs, which includes pro-osteogenic property and significant inhibition of biofilm formation and maturation, have attracted increasing interest in guided bone regeneration membrane applications.
- Participant
- Inclusion criteria 1) Articles reporting randomised controlled trials of using magnesium oxide nanoparticle based membranes 2) Invitro studies involving fabrication and evaluation of characteristics of magnesium oxide nanoparticle based membranes 3) Invivo studies which includes the use of magnesium oxide nanoparticle based membranes 4)Magnesium oxide nanoparticle in combination with other materials. Exclusion criteria 1)Review articles 2)Studies which do not have osteogenic property as outcome 3)Abstract 4)No intervention with magnesium oxide nanoparticle based membrane 5)Case reports 6)Case series
- Animal
- Human Disease Modelled
- Intervention
- Conventional biomembranes and cellulose films used in guided tissue regeneration (GTR) can prevent the downgrowth of epithelial cells, fibroblasts, and connective tissue in the area of tooth root but have limitations related to osteogenic and antimicrobial properties.Magnesium (Mg) and its alloys have gained increasing attention as a new class of biodegradable metallic material, due to their good biocompatibility and mechanical properties . However, only few studies have focused on the use of Mg alloys as barrier membranes for GBR. Magnesium oxide nanoparticles (MgONPs) possess biodegradability and lower toxicity. Furthermore, the benefits of MgONPs, which includes pro-osteogenic property and significant inhibition of biofilm formation and maturation, have attracted increasing interest in guided bone regeneration membrane applications. Inclusion criteria : Membranes which contains magnesium oxide nanoparticles Exclusion criteria : Membranes which does not contain magnesium oxide nanoparticles
- Comparator Control
- Membrane without magnesium oxide nanoparticles/ Conventional membrane
- Main Outcome
- Magnesium nanoparticle mediated bone regeneration Measures of effect Cellular proliferation and viability , Alkaline phosphatase level, Bone volume fraction, Bone mass density
- Outcome Measure
- Additional Outcome
- not applicable
- Study Method
- Systematic review
- Keyword
- Bone Regeneration; Humans; Magnesium Oxide; Nanoparticles; Osteogenesis
- Contact
- Johnisha Harris [email protected]
- Organisational Affiliation
- Saveetha Dental College and Hospital
- Funding Source
- Nil Grant number(s) State the funder, grant or award number and the date of award Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-01
- Registration Date
- 2023-08-14
- Anticipated Start Date
- 2023-03-30
- Anticipated Completion Date
- 2023-09-30
- Title Cn
- 纳米氧化镁在骨再生中的成骨潜能——一项系统评价
- Title En
- Osteogenic potential of Magnesium oxide nanoparticles in bone regeneration - A systematic review
- Bilingual Status
- complete