Meta AnalysisID 7446
疟疾对β-胡萝卜素水平的影响
CRD42023453837
Are there any difference in beta-carotene levels in malaria patients as compared to uninfected controls? We used the PICO (P: population, I: intervention, C: control, O: outcome) method to identify studies that met the i
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Record Fields
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- Meta Analysis Id
- 7446
- Evidence Id
- 16004
- Core Evidence Id
- 16004
- Source Meta Analysis Id
- 7439
- Herb2 Meta Analysis Id
- HBMA007439
- Crd Id
- CRD42023453837
- Title
- Effect of malaria on beta-carotene levels
- Review Question
- Are there any difference in beta-carotene levels in malaria patients as compared to uninfected controls? We used the PICO (P: population, I: intervention, C: control, O: outcome) method to identify studies that met the inclusion criteria. P is patients with malaria, I is none, C is patients without malaria, O beta-carotene levels.
- Study Type Included
- Inclusion criteria: Original studies in cross-sectional studies, cohort studies, case-control, and clinical trials will be considered and included for review. Exclusion criteria: case reports, case series, short reports, letters, non-original studies.
- Condition Being Studied
- Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes. Malaria remains one of the most serious infectious diseases; it threatens nearly half of the world's population and led to hundreds of thousands of deaths in 2015, predominantly among children in Africa. β-Carotene (beta-carotene) is an organic, strongly coloured red-orange pigment abundant in fungi, plants, and fruits. It is a member of the carotenes, which are terpenoids (isoprenoids), synthesized biochemically from eight isoprene units and thus having 40 carbons. Among the carotenes, β-carotene is distinguished by having beta-rings at both ends of the molecule. β-Carotene is biosynthesized from geranylgeranyl pyrophosphate. β-carotene is the most common form of carotene in plants. Plant carotenoids are the primary dietary source of provitamin A worldwide, with β-carotene as the best-known provitamin A carotenoid
- Participant
- Inclusion criteria: studies that reported beta-carotene levels in patients with malaria with any severity. Exclusion criteria: studies that reported beta-carotene levels in patients with malaria but patients were treated drugs.
- Animal
- Human Disease Modelled
- Intervention
- Comparator Control
- Inclusion criteria: studies that reported patients without malaria with data on beta-carotene levels in . Exclusion criteria: studies that reported data on beta-carotene levels in (among uninfected controls) but the information in control group could not be extracted.
- Main Outcome
- The main outcome is the pooled mean difference (or SMD) of beta-carotene levels and odds or risk of malaria infection/severity. Measures of effect The pooled mean difference (or SMD) of beta-carotene levels between malaria and non-malaria will be estimated using random effects model.
- Outcome Measure
- Additional Outcome
- The additional outcome will be the pooled mean difference (or qualitative synthesis) of beta-carotene levels between severe and non-severe malaria. Measures of effect The pooled mean difference (or SMD) of beta-carotene levels between severe and non-severe malaria will be estimated using random effects model.
- Study Method
- Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Antioxidants; Humans; Malaria; Patients; Research; beta Carotene
- Contact
- Manas KOTEPUI [email protected]
- Organisational Affiliation
- Walailak University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Thailand
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-12
- Registration Date
- 2023-08-22
- Anticipated Start Date
- 2023-08-12
- Anticipated Completion Date
- 2023-12-30
- Title Cn
- 疟疾对β-胡萝卜素水平的影响
- Title En
- Effect of malaria on beta-carotene levels
- Bilingual Status
- complete