Meta AnalysisID 7396
负载抗生素硫酸钙珠粒预防人工关节感染的有效性与安全性评价：系统评价
CRD42023489317
What are the outcomes of antibiotic-loaded calcium sulfate beads in prophylaxis of Prosthetic Joint Infections during major orthopaedic procedures
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7396
- Evidence Id
- 15954
- Core Evidence Id
- 15954
- Source Meta Analysis Id
- 7386
- Herb2 Meta Analysis Id
- HBMA007386
- Crd Id
- CRD42023489317
- Title
- Evaluating the Effectiveness and Safety of Antibiotic-Loaded Calcium Sulfate Beads in Prophylaxis of Prosthetic Joint Infections: A Systematic Review
- Review Question
- What are the outcomes of antibiotic-loaded calcium sulfate beads in prophylaxis of Prosthetic Joint Infections during major orthopaedic procedures
- Study Type Included
- Original research articles evaluating the effectiveness of antibiotic-loaded calcium sulfate beads in the prevention of prosthetic joint infections in orthopedic surgery will be included. Studies will need to provide a minimum of Level IV Evidence according to the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence.
- Condition Being Studied
- Prosthetic Joint Infections (PJIs) represent one of the most severe complications following orthopedic surgical procedures, such as hip or knee arthroplasties. These infections can lead to significant patient morbidity, increased mortality, prolonged hospitalization, and substantial financial burden on the healthcare system. The condition under review is the prophylactic application of antibiotic-loaded calcium sulfate beads during major orthopaedic procedures to prevent the occurrence of PJIs.
- Participant
- Patients undergoing major orthopedic procedures, such as joint arthroplasty, without demographic limitations, and with the use of antibiotic-loaded calcium sulfate beads for infection prophylaxis.
- Animal
- Human Disease Modelled
- Intervention
- The intervention includes the use of antibiotic-loaded calcium sulfate beads during orthopedic procedures with the intent to prevent prosthetic joint infections. The type of antibiotics used, as well as the timing and method of bead application, will be considered.
- Comparator Control
- Patients undergoing similar orthopedic procedures without the application of antibiotic-loaded calcium sulfate beads or utilizing alternative infection prophylaxis strategies will comprise the control group.
- Main Outcome
- The occurrence of PJIs as diagnosed by clinical features alongside laboratory tests such as elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, and/or positive microbial cultures from joint aspirates or periprosthetic tissues.
- Outcome Measure
- Additional Outcome
- Adverse events associated with the use of antibiotic-loaded calcium sulfate beads, including allergic reactions, toxicity, and interference with bone healing or wound healing complications Reoperation Rates Due to Infection
- Study Method
- Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Vishwa Suravaram [email protected]
- Organisational Affiliation
- Department of Orthopaedics, The Orthopaedic Research Foundation of Western Australia (ORFWA), Fremantle and Fiona Stanley Hospitals, Perth, WA, Australia https://www.orfwa.com.au/
- Funding Source
- Nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-04
- Registration Date
- 2023-12-14
- Anticipated Start Date
- 2023-12-04
- Anticipated Completion Date
- 2024-01-31
- Title Cn
- 负载抗生素硫酸钙珠粒预防人工关节感染的有效性与安全性评价：系统评价
- Title En
- Evaluating the Effectiveness and Safety of Antibiotic-Loaded Calcium Sulfate Beads in Prophylaxis of Prosthetic Joint Infections: A Systematic Review
- Bilingual Status
- complete