Meta AnalysisID 7390
磷酸钙材料定制骨植入物用于颅颌面缺损患者的系统评价
CRD42023400535
Do custom-made implants with calcium phosphate materials for defects of the cranial and maxillofacial areas confer any clinical advances over conventional implants?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7390
- Evidence Id
- 15948
- Core Evidence Id
- 15948
- Source Meta Analysis Id
- 7381
- Herb2 Meta Analysis Id
- HBMA007381
- Crd Id
- CRD42023400535
- Title
- Systematic review of custom-made bone implant with calcium phosphate materials in patients with the cranial and maxillofacial defects
- Review Question
- Do custom-made implants with calcium phosphate materials for defects of the cranial and maxillofacial areas confer any clinical advances over conventional implants?
- Study Type Included
- Full-text randomized controlled trials (RCTs) and prospective or retrospective observational studies (cohort, case-control, cross-sectional) will be eligible for inclusion in this review. Meta-analyses, systematic literature reviews, economic studies, technical articles, animal studies, biomechanical studies, cadaver studies, case reports, case series, narrative reviews, editorials, opinion pieces and letters will be excluded from the review. Studies not written in English will be also excluded in the review.
- Condition Being Studied
- In non-load-bearing areas of cranial and maxillofacial bones, complex three-dimensional bone depression deformities or defects has a significant impact on body surface morphology. Repair of these defects is expected to improve not only cosmetically, but also to give relief to psychological drawbacks and improve social performance. Currently, there are several treatment methods such as autologous bone grafting, allogenic bone grafting, and artificial bone grafting for these areas. Among them, although artificial bone the advantages of unlimited harvesting and easy aseptic manipulation, it does not have the osteoinductive capacity possessed in autogenous bone or other bone, and requires the complex shape that leads to the entry of bone marrow fluid, adhesion to the matrix bone, and replacement of bone with living bone. Therefore, "custom-made" methods may be employed to accomplish such shape. In addition, various materials are available for artificial bone implant. Among them, calcium phosphate-based materials have been often used as bone reconstruction materials because bone resorption is expected to some extent.
- Participant
- Studies involving adult patients over the age of eighteen with complex three-dimensional bone depression deformities or defects in the cranial and maxillofacial bones will be included in this systematic review of literature. Causes of these defects such as congenital bone dysplasia and acquired partial bone defects following trauma or tumor removal will be included.
- Animal
- Human Disease Modelled
- Intervention
- Studies describing surgical management with custom-made bone implants made of calcium phosphate materials that conform to the patient's bone defects or deformities implanted on the cranial and maxillofacial sites will be included in this review. Studies reporting either surgical management targeting other anatomic sites with the use of custom-made bone implants, or custom-made bone implants made of materials other than calcium phosphate materials such as hydroxyapatite or calcium phosphate will be not considered for inclusion.
- Comparator Control
- All studies comparing conventional bone implants made of any materials, including ceramic, resin, or metal, will be included. Non-comparative single-arm studies that mention the intervention of interest will be included.
- Main Outcome
- The main outcome measures of interest within this systematic literature review will be osteointegration evaluated by the fusion between the implant and bone. In addition, the secondary outcomes of interest will include but are not limited to: the subjective cosmetic outcome assessed by the patient or legal representative, coadaptation defined as a satisfactory fit between the implant and the bone defect, assessment of health-related quality of life such as SF-36 health survey, and the development of any complications after surgery, such as operative site infection, implant fracture, and failure of implant replacement.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Systematic review
- Keyword
- Calcium Phosphates; Humans; Prostheses and Implants; Skull; calcium phosphate
- Contact
- Nobuyuki Shimohata [email protected]
- Organisational Affiliation
- Ritsumeikan university
- Funding Source
- JSPS Grant-in-Aid for Scientific Research C Grant number(s) State the funder, grant or award number and the date of award Grant number JP21K05318
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Custom-made; Artificial bone implant; Cranioplasty; Maxillofacial surgery; Humans
- Published Protocol
- Review Type
- Language
- English
- Country
- Japan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-02-25
- Registration Date
- 2023-03-08
- Anticipated Start Date
- 2023-03-01
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 磷酸钙材料定制骨植入物用于颅颌面缺损患者的系统评价
- Title En
- Systematic review of custom-made bone implant with calcium phosphate materials in patients with the cranial and maxillofacial defects
- Bilingual Status
- complete