Meta AnalysisID 7351
补充肌酸或β-丙氨酸联合体育锻炼对老年人和脊髓损伤患者的影响：系统评价
CRD42023480659
Review question Does beta-alanine or creatine supplementation in the elderly and individuals with spinal cord injury, when combined with physical training, contribute to increased strength, lean mass and performance? Pop
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Record Fields
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- Meta Analysis Id
- 7351
- Evidence Id
- 15909
- Core Evidence Id
- 15909
- Source Meta Analysis Id
- 7338
- Herb2 Meta Analysis Id
- HBMA007338
- Crd Id
- CRD42023480659
- Title
- Effects of creatine or beta-alanine supplementation plus physical training in the elderly and individuals with spinal cord injury: a systematic review
- Review Question
- Review question Does beta-alanine or creatine supplementation in the elderly and individuals with spinal cord injury, when combined with physical training, contribute to increased strength, lean mass and performance? Population: Elderly and individuals with spinal cord injury Intervention: Supplementation with creatine or beta-alanine, associated with training Control: Randomized clinical study Outcome: Increase in strength, lean mass or performance
- Study Type Included
- Only randomized clinical trials were included.
- Condition Being Studied
- In aging, sarcopenia leads to loss of strength, lean mass and suboptimal physical performance. These changes occur due to the gradual reduction of skeletal muscle fibers and their replacement by adipose tissue and collagen, leading to changes in the articular cartilage that result in biomechanical changes, which, in turn, affect motor function. Loss of motor function also occurs in spinal cord injury, due to muscular atrophy resulting from immobilization and denervation of skeletal muscle. Skeletal muscular atrophy and the accumulation of intramuscular fat greatly impact an individual's autonomy and quality of life and represent a risk factor for diseases such as obesity, type II diabetes and metabolic syndrome.
- Participant
- Among the inclusion criteria are studies that: (1) intervened in the target population, in this case, the elderly and individuals with spinal cord injury, (2) were randomized or controlled clinical trials, and (3) were available in Portuguese or English.
- Animal
- Human Disease Modelled
- Intervention
- The exclusion criteria were: (1) studies that used multi-ingredient ergogenic supplements containing creatine and/or beta-alanine mixed, and/or did not present the two supplements studied in isolation, (2) studies that did not have a training protocol associated with the supplementation, (3) studies that did not describe the supplementation protocol, (4) studies involving individuals undergoing treatment for comorbidities, (5) studies for which the full article was not accessible.
- Comparator Control
- As comparator(s)/control, only randomized clinical studies were used, in which there was a control group and/or placebo group
- Main Outcome
- As pre-specified main results of the review, it is expected to observe a gain in muscle mass, strength and performance, both in the elderly and in individuals with spinal cord injury, after supplementation associated with training. To measure this gain, the study must necessarily present a detailed training protocol. Measures of effect Not applicable
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Camila Brauna [email protected]
- Organisational Affiliation
- University of Brasilia
- Funding Source
- All authors are affiliated with the University of Brasília. And one of the authors, THMC, is grateful for the scientific grant from FAPDF (Fundação de Amparo à Pesquisa do Distrito Federal) n. 281/2021; Process. 00193-00001015/2021-71.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil
- Country
- Brazil, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-11-07
- Registration Date
- 2023-11-20
- Anticipated Start Date
- 2023-11-07
- Anticipated Completion Date
- 2023-12-07
- Title Cn
- 补充肌酸或β-丙氨酸联合体育锻炼对老年人和脊髓损伤患者的影响：系统评价
- Title En
- Effects of creatine or beta-alanine supplementation plus physical training in the elderly and individuals with spinal cord injury: a systematic review
- Bilingual Status
- complete