Meta AnalysisID 735
肉桂酸及其天然衍生物对糖尿病血糖控制的影响：临床前体内证据的系统评价
CRD42021278180
Do effects of cinnamic acid and its derivatives in diabetic animal experiments help in glycemic control and liver and kidney biomarkers? Context and rationale Studies on the effect of cinnamic acid in the treatment of di
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Record Fields
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- Meta Analysis Id
- 735
- Evidence Id
- 9293
- Core Evidence Id
- 9293
- Source Meta Analysis Id
- 712
- Herb2 Meta Analysis Id
- HBMA000712
- Crd Id
- CRD42021278180
- Title
- Effect of cinnamic acid and natural derivatives on glycemic control in Diabetes Mellitus: a systematic review of preclinical in vivo evidence
- Review Question
- Do effects of cinnamic acid and its derivatives in diabetic animal experiments help in glycemic control and liver and kidney biomarkers? Context and rationale Studies on the effect of cinnamic acid in the treatment of diabetes have been published in recent years. Even though, the knowledge about its effects is still scarce, which difficults the understanding of its mechanism of action. In addition, a deep and specific meta-analysis of the effect of cinnamic acid over diabetes treatment has yet to be done. Therefore, we believe that this meta-analysis will shed light on the real potential of cinnamic acid as an antidiabetic so that we can consolidate it as a potential medicine for human use.
- Study Type Included
- Inclusion criteria: In vivo experimental studies are eligible, provided they have a diabetic control group and a diabetic group treated with cinnamic acid (controlled studies with separate treatment groups) Exclusion criteria: Studies without an untreated diabetic group as a control
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: We will only include rodents (rat and mouse) as an animal model of diabetes. There will be no restriction on the model of induced diabetes. Exclusion criteria: Clinical, in vitro and ex vivo studies will be excluded from the review.
- Human Disease Modelled
- Diabetes mellitus type 1 or type 2
- Intervention
- Inclusion criteria: We will include studies using cinnamic acid and derivatives from plant extracts, as well from commercial laboratories. We will include treatments using cinnamic acid and derivatives in different concentrations, routes of administration, frequency of treatment and time. Exclusion criteria: Studies in which it was not clear the presence of cinnamic acid and derivatives during the treatment.
- Comparator Control
- Inclusion criteria: Experimental studies with control (diabetic animals) and treatment (diabetic animals treated with cinnamic acid and derivatives) groups. Exclusion criteria: Studies with absence of one of these groups.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Blood glucose levels, glycated hemoglobin and insulin resistance parameters will be considered for this study. Exclusion criteria: Studies that report other parameters such as weight, oxidative stress, inflammatory and histological parameters, but that do not present blood glucose levels will not be considered for this review.
- Additional Outcome
- Study Method
- Keyword
- Animals; Blood Glucose; Cinnamates; Diabetes Mellitus; Glycemic Control; cinnamic acid
- Contact
- Amanda dos Santos Lima [email protected]
- Organisational Affiliation
- Federal University of Alfenas https://www.unifal-mg.edu.br/
- Funding Source
- For this and other work, we received financial support from the Higher Education Improvement Coordination (CAPES), the National Council for Scientific and Technological Development (CNPq) and the Minas Gerais Research Support Foundation (FAPEMIG)
- Other Selection Criteria
- Only studies published in English, Spanish or Portuguese will be included. Reviews, conference abstracts and letters to the editor will not be considered.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-13
- Registration Date
- 2021-12-13
- Anticipated Start Date
- 2021-09-10
- Anticipated Completion Date
- 2022-05-01
- Title Cn
- 肉桂酸及其天然衍生物对糖尿病血糖控制的影响：临床前体内证据的系统评价
- Title En
- Effect of cinnamic acid and natural derivatives on glycemic control in Diabetes Mellitus: a systematic review of preclinical in vivo evidence
- Bilingual Status
- complete