Meta AnalysisID 7328
不同浓度阿托品对儿童青少年近视的疗效和耐受性：系统评价与Meta分析的伞形评价
CRD42023466785
What's the best concentration of atropine to slow myopia progression in children and adolescent? What's the most effective and tolerable protocol to control myopia using atropine?
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Record Fields
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- Meta Analysis Id
- 7328
- Evidence Id
- 15886
- Core Evidence Id
- 15886
- Source Meta Analysis Id
- 7316
- Herb2 Meta Analysis Id
- HBMA007316
- Crd Id
- CRD42023466785
- Title
- Efficacy and tolerability of different concentrations atropine in children and adolescent with myopia: an umbrella review of systematic reviews and meta-analyses
- Review Question
- What's the best concentration of atropine to slow myopia progression in children and adolescent? What's the most effective and tolerable protocol to control myopia using atropine?
- Study Type Included
- Inclusion criteria 1) study type: systematic review or meta-analysis based on randomized control trials or observational studies on the topic of myopia control; 2) population: patients in RCTs or observational studies aged under 18 years old with myopia; 3) intervention and control: the intervention group received atropine drops with the concentration various from 0.01% to 1%, control group should be saline, placebo or blank control. Studies comparing the other myopia control approaches and atropine plus approaches were also included; 4) report of outcomes: main outcomes that included the changing of spherical equivalent refraction (SER) or axial length in mean±standard deviation form or 95% credible interval. Exclusion criteria 1) studies reporting the atropine used in animals; 2) studies of protocol, conference abstracts, network meta-analysis, articles without full-text; 3) articles reporting unavailable data.
- Condition Being Studied
- Myopia, short sightness, near-eyesight
- Participant
- We will include all systematic reviews on human participants, irrespective of sex and setting (inpatient, outpatient, or community setting), participating in placebo- or active-controlled RCTs or observational studies studying atropine used in myopia control. Participants who will included should be diagnosed by optometry that the refractions were less than -0.5D, for the reason that we intend to investigate the efficacy of atropine in slowing children and adolescent myopia, participants shou aged under 18 years old.
- Animal
- Human Disease Modelled
- Intervention
- Different concentration of atropine, or atropine plus other myopia controlling approaches.
- Comparator Control
- Blank or placebo drops that was proved not to control myopia, other myopia controlling approaches.
- Main Outcome
- Primary outcomes will be efficacy of myopia progression, defined as spherical equivalent error (SER) change and axial length change; Secondary outcomes included the adverse events during the trials or atropine treatment. Measures of effect Due to the continuous variants type, we measure the main outcomes using MDs (mean differences) in the meta-analyses.
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Review of reviews, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Zhaotian Zhang [email protected]
- Organisational Affiliation
- Zhongshan Ophthalmic Center, Sun-Yat-sen University
- Funding Source
- Supported by Natural Science Foundation of Guangdong Province, China Grant number(s) State the funder, grant or award number and the date of award Natural Science Foundation of Guangdong Province, China(2023A1515011652)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-26
- Registration Date
- 2023-10-07
- Anticipated Start Date
- 2023-08-01
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 不同浓度阿托品对儿童青少年近视的疗效和耐受性：系统评价与Meta分析的伞形评价
- Title En
- Efficacy and tolerability of different concentrations atropine in children and adolescent with myopia: an umbrella review of systematic reviews and meta-analyses
- Bilingual Status
- complete