Meta AnalysisID 7324
阿托品控制近视疗效的最新进展：系统评价与Meta分析
CRD42023454104
What is the effectiveness, safety, rebound, adverse events and side effects of atropine in children?
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Record Fields
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- Meta Analysis Id
- 7324
- Evidence Id
- 15882
- Core Evidence Id
- 15882
- Source Meta Analysis Id
- 7312
- Herb2 Meta Analysis Id
- HBMA007312
- Crd Id
- CRD42023454104
- Title
- An update on the efficacy of atropine for myopia control: a systematic review and meta-analysis
- Review Question
- What is the effectiveness, safety, rebound, adverse events and side effects of atropine in children?
- Study Type Included
- Only RCTs
- Condition Being Studied
- Myopia is a public health problem with increasing prevalence in East Asian Countries. However, in the past few decades myopia prevalence has also increased in other countries in North America and Europe. Myopia poses a significantly increased risk of sight threatening ocular conditions such as retinal detachment, macular degeneration, glaucoma and cataract. Preventing the development of myopia and slowing down/halting its progression in early life is important to control myopia.
- Participant
- Inclusion: Children under 18 years of age with and without myopia. Exclusion: Children over 16 years of age at baseline, with other ocular disease or condition, underwent ocular surgery or using another intervention method for myopia different from atropine eye drops.
- Animal
- Human Disease Modelled
- Intervention
- Atropine eye drops of various concentrations available are the interventions (low 0.01%, moderate 0.02% to 0.25%, and high 0.5% to 1%).
- Comparator Control
- The control group will be treated with placebo/non-exposed to atropine
- Main Outcome
- Change in ocular refraction (in dioptres), axial length (in millimetres), pupil diameter (in millimetres), amplitude of accommodation (in dioptres), and distance and near best-corrected visual acuity (in logarithm of the minimum angle of resolution), Measures of effect Mean difference, standard deviation, 95% confidence interval
- Outcome Measure
- Additional Outcome
- Rebound effect, adverse effect and side effect, eyes showing rapid myopia progression Measures of effect Proportion (%)
- Study Method
- Intervention, Meta-analysis, Prognostic, Systematic review
- Keyword
- Atropine; Child; Humans; Mydriatics; Myopia
- Contact
- Sayantan Biswas [email protected]
- Organisational Affiliation
- Aston University, United Kingdom Escola Superior de Tecnologia da Saúde de Lisboa, Portugal Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland
- Funding Source
- None of the authors received any funding for this review
- Other Selection Criteria
- Final Publication
- Same Topic Review
- This review is an update of our earlier systematic review: Lanca C, Pang CP, Grzybowski A. Effectiveness of myopia control interventions: A systematic review of 12 randomized control trials published between 2019 and 2021. Front Public Health. 2023;11:1125000. This review will update our understanding of atropine's efficacy and safety.
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Poland, Portugal
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-17
- Registration Date
- 2023-08-21
- Anticipated Start Date
- 2023-08-18
- Anticipated Completion Date
- 2023-12-01
- Title Cn
- 阿托品控制近视疗效的最新进展：系统评价与Meta分析
- Title En
- An update on the efficacy of atropine for myopia control: a systematic review and meta-analysis
- Bilingual Status
- complete